Mounzer A M, McAninch J W, Schmidt R A
Urology. 1986 Aug;28(2):127-30. doi: 10.1016/0090-4295(86)90103-2.
To evaluate the use of a polyglycolic acid (PGA) mesh graft for partial nephrectomy, we replaced the upper pole of the left kidney in 12 New Zealand white rabbits with a free omental fat graft and the lower pole with PGA mesh. The mesh stopped the bleeding immediately during the operation. At forty-eight hours, the fibers were still intact, with an organized clot on the surface of the mesh. Between two weeks and two months, the fibers had begun to be digested by histiocytes, with formation of giant cells and fibroblastic proliferation with collagen deposition around the mesh. At three months, there was complete resorption of the PGA mesh and formation of a new fibrous capsule. There was no renal reaction and no difference between the PGA mesh and the omental fat graft. We believe that PGA mesh can be helpful in repairing injured kidneys by securing hemostasis and serving as a scaffold for the formation of a new capsule.
为评估聚乙醇酸（PGA）网片移植在部分肾切除术中的应用，我们在12只新西兰白兔身上进行了实验，用游离网膜脂肪移植替换左肾上极，用PGA网片替换下极。手术过程中网片立即止血。48小时时，纤维仍完整，网片表面有组织化的血凝块。在两周至两个月之间，纤维开始被组织细胞消化，形成巨细胞，网片周围有成纤维细胞增殖并伴有胶原沉积。三个月时，PGA网片完全吸收，形成新的纤维囊。未出现肾脏反应，PGA网片与网膜脂肪移植之间无差异。我们认为，PGA网片可通过确保止血并作为形成新囊的支架，有助于修复受损肾脏。
