Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, China; Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.
Department of Pathogenic Biology, School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, China; The First People's Hospital of Yibin, Yibin, 644000, Sichuan, China.
Microb Pathog. 2018 Nov;124:301-304. doi: 10.1016/j.micpath.2018.08.055. Epub 2018 Aug 27.
Hypervirulent variants of klebsiella pneumoniae (hvKP), which cause serious infections not only healthy individuals, but also the immunocompromised patients, have been increasingly reported recently. One conjugation of a hypermucoviscous strian SWU01 co-carried the resistance gene bla and virulence gene iroN by the PCR detection from three carbapenem-resistance hvKP. To know the genetic context of this plasmid. The whole genome of this strain was sequenced. We got a 162,552-bp plasmid (pSWU01) which co-carried the resistance gene bla and virulence gene iroN. It is composed of a typical IncFII-type backbone, five resistance genes including bla, bla, bla, bla and rmtB, and several virulence relevant factors including iroN, traT and toxin-antitoxin systems. The plasmid pSWU01 co-carrying the multidrug resistance determinants and virulence relevant factors from the hypermucoviscous K. pneumoniae represents a novel therapeutic challenge.
最近，越来越多的报道称，肺炎克雷伯菌（Klebsiella pneumoniae）的高毒力变异株（hvKP）不仅会导致健康个体，还会导致免疫功能低下的患者发生严重感染。通过 PCR 检测，从三株碳青霉烯类耐药性 hvKP 中发现一株超黏液性 SWU01 菌株发生了一次接合，该菌株同时携带了耐药基因 bla 和毒力基因 iroN。为了了解该质粒的遗传背景，我们对该菌株的全基因组进行了测序。我们得到了一个 162552bp 的质粒（pSWU01），该质粒同时携带了耐药基因 bla 和毒力基因 iroN。它由一个典型的 IncFII 型骨架组成，包含五个耐药基因，包括 bla、bla、bla、bla 和 rmtB，以及几个与毒力相关的因子，包括 iroN、traT 和毒素-抗毒素系统。该质粒 pSWU01 同时携带了高黏液性肺炎克雷伯菌的多药耐药决定因子和与毒力相关的因子，这代表了一个新的治疗挑战。
