Labakhua T Sh, Kokaia M G, Okudzhava V M
Neirofiziologiia. 1986;18(3):298-306.
Intracellular correlates of evoked rhythmic cortical "spike-and-wave" potentials produced in sensorimotor cortex during 3/s stimulation of the thalamic relay nucleus (VPL) and of self-sustained "spike-and-wave" afterdischarges following 8-14/s stimulation of the same nucleus were studied in acute experiments on cats immobilized by myorelaxants. Intracellular recordings of pyramidal tract neurons revealed that different components of evoked "spike-and-wave" potentials, i. e. the spike-like negative wave and the long lasting negative wave, are postsynaptic in origin: the first is due to EPSPs with spike discharges, and the latter--to IPSPs of cortical neurons. Components of "spike-and-wave" afterdischarge mostly reflect the paroxysmal depolarizing shifts of the membrane potential of cortical neurons. After cessation of sustained "spike-and-wave" activity the long-lasting hyperpolarization accompanied by inhibition of spike discharges and subsequent recovery was observed in cortical neurons. It is presumed that the negative wave of the evoked "spike-and-wave" potential as well as slow negative potentials of direct cortical and primary responses reflect IPSPs of deeper parts of pyramidal tract neurons, while the waves of the sustained "spike-and-wave" afterdischarges are due to paroxysmal depolarizing shifts in cortical neurons.
在对用肌松剂固定的猫进行的急性实验中，研究了在以3次/秒的频率刺激丘脑中继核（VPL）时，感觉运动皮层中诱发的节律性皮层“棘波-慢波”电位的细胞内相关性，以及在以8 - 14次/秒的频率刺激同一核团后出现的自维持“棘波-慢波”后放电的细胞内相关性。锥体束神经元的细胞内记录显示，诱发的“棘波-慢波”电位的不同成分，即棘状负波和持续时间较长的负波，均起源于突触后：第一个成分是由于伴有棘波放电的兴奋性突触后电位（EPSPs），而后者是由于皮层神经元的抑制性突触后电位（IPSPs）。“棘波-慢波”后放电的成分大多反映了皮层神经元膜电位的阵发性去极化偏移。在持续的“棘波-慢波”活动停止后，在皮层神经元中观察到了伴随棘波放电抑制的长时间超极化以及随后的恢复。据推测，诱发的“棘波-慢波”电位的负波以及直接皮层反应和初级反应的慢负电位反映了锥体束神经元深部的抑制性突触后电位，而持续的“棘波-慢波”后放电的波则是由于皮层神经元的阵发性去极化偏移所致。
