Labakhua T Sh, Kokaia M G, Okudzhava V M
Neirofiziologiia. 1986;18(3):319-25.
In acute unanesthetized immobilized cats a sequence of fast hyperpolarization and long-lasting depolarization was found in pyramidal tract neurons of the sensorimotor cortex during tetanic stimulation (8-14/s for 10 s) of the ventro-postero-lateral nucleus of the thalamus. During long-lasting depolarization after cessation of stimulation self-sustained rhythmic paroxysmal depolarizing membrane potential shifts appeared which were terminated by long-lasting hyperpolarization. In glial cells only depolarization was observed during stimulation as well as during self-sustained "spike-and-wave" rhythmic activity. Hyperpolarization in glial cells appeared only after its termination in neurons. It is suggested that the long-lasting changes in the membrane potential of cortical elements may play a particular role in formation and cessation of "spike-and-wave" rhythmical activity.
在急性未麻醉的固定猫中，当对丘脑腹后外侧核进行强直刺激（8 - 14次/秒，持续10秒）时，在感觉运动皮层的锥体束神经元中发现了一系列快速超极化和持久去极化现象。在刺激停止后的持久去极化期间，出现了自维持的节律性阵发性去极化膜电位变化，这些变化被持久超极化终止。在神经胶质细胞中，在刺激期间以及自维持的“棘波 - 慢波”节律性活动期间仅观察到去极化。神经胶质细胞中的超极化仅在神经元中的超极化终止后才出现。有人提出，皮层元件膜电位的持久变化可能在“棘波 - 慢波”节律性活动的形成和终止中起特殊作用。
