Nikol'skiĭ E E, Voronin V A
Neirofiziologiia. 1986;18(3):361-7.
The spontaneous quantal and nonquantal acetylcholine release was investigated at the temperature range from 10 to 35 degrees C in white mouse semidiaphragm. The quantal release was evaluated by calculation of miniature end-plate potentials frequency, while the nonquantal one--from the H-effect value. The spontaneous quantal release increased exponentially with the temperature growth. The temperature dependence of the nonquantal release showed two relative maxima: at 20 degrees and 35 degrees C. At 10 degrees C the nonquantal release was absent. The value of calculated effective energy of activation of the quantal release was 57.0 kJ/mol in the investigated temperature range. The effective energy of activation for the nonquantal release process in intervals 15-20 degrees C and 25-35 degrees C was 45.5 and 38.2 kJ/mol, relatively. It is suggested that the nonquantal release is rather due to active transport processes than to simple diffusion of acetylcholine molecules.
在10至35摄氏度的温度范围内，对白鼠半膈肌的自发性量子化和非量子化乙酰胆碱释放进行了研究。通过计算微小终板电位频率来评估量子化释放，而非量子化释放则根据H效应值进行评估。自发性量子化释放在温度升高时呈指数增加。非量子化释放的温度依赖性呈现两个相对最大值：分别在20摄氏度和35摄氏度时。在10摄氏度时不存在非量子化释放。在所研究的温度范围内，计算得出的量子化释放有效活化能值为57.0 kJ/mol。在15至20摄氏度和25至35摄氏度区间内，非量子化释放过程的有效活化能分别为45.5 kJ/mol和38.2 kJ/mol。研究表明，非量子化释放更可能是由于主动转运过程，而非乙酰胆碱分子的简单扩散。
