Degtiarenko A M
Neirofiziologiia. 1986;18(3):392-402.
The role of presynaptic and postsynaptic processes in formation of the long-term (hundreds of milliseconds) activity of neuronal networks was analyzed by the mathematical simulation model. The long-term activity of networks with presynaptic inhibition was discontinued due to the depolarization of the neuronal terminals that achieved its critical level and to significant suppression of the effectiveness of synaptic interaction. The long-term activity of networks with postsynaptic inhibition was discontinued because of the activation of inhibitory neurons exerting strong hyperpolarizing effects on other neurons of the networks. Synchronization of neuronal discharges was important in achievement of the critical level by terminal depolarization or inhibitory postsynaptic processes that interrupted the network activity. Properties of neuronal networks with presynaptic and postsynaptic inhibition were compared with those of uniform neuronal networks (with a positive feedback between neurons only). It is concluded that introduction of the additional negative feedback circuits in a form of presynaptic or postsynaptic inhibition contributes to improvement of reliability and accuracy of the mechanism which terminates the network activity.
通过数学模拟模型分析了突触前和突触后过程在神经网络长期（数百毫秒）活动形成中的作用。具有突触前抑制的网络的长期活动由于神经元终末达到临界水平的去极化以及突触相互作用有效性的显著抑制而终止。具有突触后抑制的网络的长期活动由于抑制性神经元的激活而终止，这些抑制性神经元对网络中的其他神经元施加强烈的超极化作用。神经元放电的同步在通过终末去极化或抑制性突触后过程达到临界水平从而中断网络活动方面很重要。将具有突触前和突触后抑制的神经网络的特性与均匀神经网络（仅神经元之间存在正反馈）的特性进行了比较。得出的结论是，以突触前或突触后抑制形式引入额外的负反馈回路有助于提高终止网络活动机制的可靠性和准确性。
