a Faculty of Medicine , Titu Maiorescu University , Bucharest , Romania.
b Center for Military Medical Scientific Research , Bucharest , Romania.
J Enzyme Inhib Med Chem. 2018 Dec;33(1):1292-1298. doi: 10.1080/14756366.2018.1499626.
The current study was conducted on a sample of 91 patients diagnosed with diastolic dysfunction (DD) with preserved systolic function caused by a painful chronic ischaemic cardiopathy - angina pectoris stable at the effort. The diagnosis was established following anamnesis, electrocardiogram, and echocardiography. Myeloperoxidase (MPO) serum levels were assessed in all patients and then these values were correlated with some of the echocardiography parameters that proved the mentioned diagnosis. In conclusion, the execution of this investigation triad (electrocardiogram, echocardiography, and MPO) allows: Stratifying the patients depending on the disease risk by early detecting of any possible DD with preserved systolic function. The use of the MPO increased circulating levels as a biomarker for diagnosis and risk due to the statistically significant correlation between those and the results of the other two aforementioned paraclinical investigation.
本研究对 91 例因慢性缺血性心脏病（稳定劳力型心绞痛）导致的收缩功能正常的舒张功能障碍（DD）患者进行了研究。诊断依据为病史、心电图和超声心动图。所有患者均评估了髓过氧化物酶（MPO）血清水平，并将这些值与一些超声心动图参数相关联，这些参数证明了上述诊断。总之，执行这一三联（心电图、超声心动图和 MPO）检查可以：通过早期发现任何可能存在的收缩功能正常的舒张功能障碍，对患者进行疾病风险分层。由于 MPO 增加了循环水平，作为诊断和风险的生物标志物，因为它与上述两种其他临床前检查的结果之间存在统计学显著相关性。
