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脂蛋白相关磷脂酶 A2（Lp-PLA2）- 慢性缺血性心脏病的可能诊断和风险生物标志物。

Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease.

机构信息

Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania.

出版信息

J Enzyme Inhib Med Chem. 2021 Dec;36(1):68-73. doi: 10.1080/14756366.2020.1839447.

DOI:10.1080/14756366.2020.1839447
PMID:33187461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7671608/
Abstract

In a group of 208 patients with chronic ischaemic heart disease, the variation of A-associated-LDL phosphatase (Lp-PLA) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy.

摘要

在一组 208 例慢性缺血性心脏病患者中，分析了血清 A 相关脂蛋白磷酸酶（Lp-PLA）浓度值在两周间隔内的动态变化。研究的结论是，血清 Lp-PLA 浓度值可作为慢性缺血性心脏病的诊断特异性生物标志物，在临床上报告存在心绞痛但心电图无特异性变化的患者，以及评估个体化治疗反应的情况下，该参数在医学实践中具有实际应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/5257f2d5fa1f/IENZ_A_1839447_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/7f828ef42157/IENZ_A_1839447_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/e41e1b97e22b/IENZ_A_1839447_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/4241a47aa523/IENZ_A_1839447_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/af8b5a59b798/IENZ_A_1839447_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/5257f2d5fa1f/IENZ_A_1839447_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/7f828ef42157/IENZ_A_1839447_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/e41e1b97e22b/IENZ_A_1839447_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/4241a47aa523/IENZ_A_1839447_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/af8b5a59b798/IENZ_A_1839447_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30a6/7671608/5257f2d5fa1f/IENZ_A_1839447_F0005_C.jpg

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