Cone E J, Johnson R E, Moore J D, Roache J D
Pharmacol Biochem Behav. 1986 Jun;24(6):1749-54. doi: 10.1016/0091-3057(86)90515-0.
Four healthy male subjects smoked two marijuana cigarettes or one marijuana cigarette and one placebo cigarette, or two placebo cigarettes on separate days in a random order crossover design. Each marijuana cigarette contained 2.8% delta-9-tetrahydrocannabinol (THC). Plasma hormones and THC were measured before and after each smoking session. Plasma LH was significantly depressed and cortisol was significantly elevated after smoking marijuana. Nonsignificant depressions of prolactin, FSH, testosterone and free testosterone and elevation of GH also occurred. Concurrent measures of subjective effects via subscales of the Addiction Research Center Inventory, Single Dose Questionnaire and a Visual Analog Scale were generally elevated. Significant impairment on a psychomotor performance task paralleled elevations in subjective effects, hormone effects and peak THC determinations. Although all the hormone effects were within normal basal ranges, interactions between these systems, and their effects on behavior cannot be discounted.
四名健康男性受试者按照随机顺序交叉设计，在不同日期分别吸食两支大麻烟、一支大麻烟和一支安慰剂烟或两支安慰剂烟。每支大麻烟含有2.8%的Δ-9-四氢大麻酚（THC）。在每次吸烟前后测量血浆激素和THC水平。吸食大麻后，血浆促黄体生成素（LH）显著降低，皮质醇显著升高。催乳素、促卵泡生成素（FSH）、睾酮和游离睾酮也有不显著的降低，生长激素（GH）升高。通过成瘾研究中心量表、单剂量问卷和视觉模拟量表的分量表对主观效应进行的同步测量总体上有所升高。一项心理运动表现任务的显著受损与主观效应、激素效应和THC峰值测定的升高平行。尽管所有激素效应都在正常基础范围内，但这些系统之间的相互作用及其对行为的影响不容忽视。
