Faculty of Science and Industrial Technology, Prince of Songkla University, Suratthani Campus, Surat Thani, 84000, Thailand.
J Nat Med. 2019 Jan;73(1):273-277. doi: 10.1007/s11418-018-1246-2. Epub 2018 Aug 30.
Three new dihydrobenzofuran neolignans, myticaganal A-C (1-3), along with five known compounds (4-8), were isolated from the seeds of Myristica fragrans. Their structures were elucidated by extensive spectroscopic analysis. In vitro cytotoxic activities of the isolated compounds against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer) were evaluated. Neolignan 3 showed significant cytotoxicity against KB and NCI-H187 cell lines with IC values of 5.9 and 6.3 μM, respectively.
从肉豆蔻种子中分离得到三种新的二氢苯并呋喃新木脂素，即迷蒂卡苷 A-C（1-3），以及五种已知化合物（4-8）。通过广泛的光谱分析阐明了它们的结构。对分离得到的化合物对三种人癌细胞系（KB、口腔；MCF-7、乳腺癌；NCI-H187、小细胞肺癌）的体外细胞毒性进行了评价。新木脂素 3 对 KB 和 NCI-H187 细胞系表现出显著的细胞毒性，IC 值分别为 5.9 和 6.3 μM。
