State Key Laboratory of Quality Research in Chinese Medicine, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau 999078, China.
Increasepharm(Hengqin) Institute Co., Limited, National Engineering Research Center for Modernization of Traditional Chinese Medicine New DDS Branch, Guangdong Province Engineering Research Center for Aerosol Inhalation Preparation, Zhuhai 519000, China.
J Agric Food Chem. 2022 Aug 10;70(31):9684-9693. doi: 10.1021/acs.jafc.2c03370. Epub 2022 Jul 29.
The seed of Houtt (nutmeg) is one of the important spices that have been extensively used in the culinary, food, beverage, and also in medicinal products industry. Previous phytochemical studies on nutmeg were mainly focused on lignans and neolignans. However, the other constituents have been poorly studied. In this study, 11 new monoterpene-conjugated phenolic derivatives, named myrifratins A-K (-), and five known compounds were isolated from nutmeg. The novel neolignan-diarylnonanoid-monoterpene conjugates ( and ) were first isolated in nature. Compounds - were rarely monoterpene-diarylnonanoid-conjugated derivatives, and - were the first examples of monoterpene-neolignan conjugates. Compounds -, , and showed potent autophagy inhibitory activities in a concentration-dependent manner. Our findings showed an uncommon class of monoterpene-conjugated phenolic derivatives in nature and reported their autophagy inhibition activities for the first time, which may give a new insight into the benefits or safety of nutmeg in foods.
荜茇种子是一种重要的香料，广泛应用于烹饪、食品、饮料和医药产品行业。以前对荜茇的植物化学研究主要集中在木脂素和新木脂素上，而其他成分则研究较少。在这项研究中，从荜茇中分离得到了 11 种新的单萜共轭酚类衍生物，命名为 myrifratins A-K(-)，以及 5 种已知化合物。新型的新木脂素-二芳基壬烷-单萜轭合物(和)首次在自然界中分离得到。化合物-很少见单萜-二芳基壬烷轭合物，而-是单萜-新木脂素轭合物的第一个例子。化合物-、-和-在浓度依赖性方式下表现出强烈的自噬抑制活性。我们的研究结果显示了自然界中一类不常见的单萜共轭酚类衍生物，并首次报道了它们的自噬抑制活性，这可能为荜茇在食品中的益处或安全性提供了新的见解。
