Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Department of Pediatrics, PGIMER, Chandigarh, India.
Mycopathologia. 2019 Feb;184(1):151-154. doi: 10.1007/s11046-018-0294-1. Epub 2018 Aug 30.
Aspergillus terreus may colonize the airways of patients with cystic fibrosis (CF). Whether this merits antifungal treatment is still unclear due to heterogeneous reports regarding its pathogenic potential. Although allergic manifestations are documented, invasive aspergillosis (IA) caused by A. terreus has not been described. We present here one case of probable IA caused by A. terreus, highlighting its role as an emerging agent of IA in CF patients. Voriconazole was effective, and the patient was healthy after 12 weeks of treatment. Serial determination of serum galactomannan level and periodic cultures from respiratory specimens may help in monitoring CF patients by identifying such pathogens. Further studies on the fungal species colonizing the CF airways are warranted, especially in India. This case report suggests A. terreus as a potential agent of IA which should not be ignored, particularly in this patient group.
土曲霉可能定植于囊性纤维化（CF）患者的气道中。由于其潜在致病性的报告存在差异，因此是否需要抗真菌治疗尚不清楚。虽然已记录到过敏表现，但由土曲霉引起的侵袭性曲霉病（IA）尚未被描述。我们在此介绍了一例由土曲霉引起的疑似 IA，突出了其在 CF 患者中作为新兴 IA 病原体的作用。伏立康唑治疗有效，患者在 12 周的治疗后恢复健康。定期检测血清半乳甘露聚糖水平和呼吸道标本的培养可能有助于通过鉴定此类病原体来监测 CF 患者。需要进一步研究 CF 气道定植的真菌种类，特别是在印度。本病例报告提示土曲霉可能是 IA 的潜在病原体，不应被忽视，尤其是在该患者群体中。
