Allmann D W, Dunipace A, Jaouni S, Curro F A
Res Commun Chem Pathol Pharmacol. 1986 Jun;52(3):275-84.
Evidence is presented that accumulation of cAMP in isolated rat thoracic aorta and diaphragm is stimulated by several fluorine containing compounds (NaF, Na2PO3F (MFP) and SnF2). Time course experiments with NaF showed that maximal stimulation of cAMP accumulation was observed within 2.5 min. NaF and MFP produced significant increases in cAMP accumulation at concentrations of 0.1 microM and SnF2 produced a significant increase at 0.01 microM. The sensitivity of these tissues to the fluorine compounds is similar to that previously reported (Curro and Mickunas, 1981) for the inhibition of norepinephrine induced contractions by fluorine compounds in isolated thoracic aorta.
有证据表明，几种含氟化合物（氟化钠、单氟磷酸钠（MFP）和氟化亚锡）可刺激离体大鼠胸主动脉和膈肌中cAMP的积累。用氟化钠进行的时间进程实验表明，在2.5分钟内观察到cAMP积累的最大刺激。氟化钠和MFP在0.1微摩尔浓度时可显著增加cAMP积累，而氟化亚锡在0.01微摩尔浓度时可显著增加。这些组织对氟化合物的敏感性与先前报道的（Curro和Mickunas，1981年）离体胸主动脉中氟化合物抑制去甲肾上腺素诱导的收缩的敏感性相似。
