Costello C, Treacy M, Lai L
Scand J Haematol. 1986 May;36(5):507-10. doi: 10.1111/j.1600-0609.1986.tb02288.x.
Over the past 3 yr we have treated 6 homosexual men (age 22-55 yr) with immune thrombocytopenic purpura. 4 of the 6 have antibody to HTLV-III in their serum, 1 of these patients has the acquired immune deficiency syndrome (AIDS), 1 has AIDS-related-complex (ARC), and a 3rd has persistent generalised lymphadenopathy (PGL). The platelet count at presentation was between 2 and 35 X 10(9)/l and in each case a bone marrow confirmed active platelet production. Antiplatelet antibodies were demonstrated in 3 of 4 patients tested. 3 of the 6 patients showed a partial response to prednisolone, 2 showed little or no response and the 6th showed a good response. 2 patients received high dose i.v. immunoglobulin - 1 had an excellent response prior to splenectomy, the other showed no response. 5 of the 6 patients had a splenectomy. 3 had a lasting remission (12-27 months after splenectomy), 1 of these has HTLV-III antibodies; 1 had a remission lasting 1 yr, followed by fluctuating thrombocytopenia (21-130 X 10(9)/l) and 1 showed no response.
在过去3年中，我们对6名免疫性血小板减少性紫癜的同性恋男性患者（年龄22 - 55岁）进行了治疗。6名患者中有4名血清中含有抗HTLV - III抗体，其中1名患者患有获得性免疫缺陷综合征（AIDS），1名患有艾滋病相关综合征（ARC），第3名患有持续性全身性淋巴结病（PGL）。就诊时血小板计数在2至35×10⁹/L之间，且每例患者骨髓检查均证实有活跃的血小板生成。在接受检测的4名患者中有3名检测出抗血小板抗体。6名患者中有3名对泼尼松龙有部分反应，2名反应甚微或无反应，第6名反应良好。2名患者接受了大剂量静脉注射免疫球蛋白治疗，1名在脾切除术前有极佳反应，另1名无反应。6名患者中有5名接受了脾切除术。3名患者获得持久缓解（脾切除术后12 - 27个月），其中1名有HTLV - III抗体；1名缓解持续1年，随后血小板减少波动（21 - 130×10⁹/L），1名无反应。
