Gazzard B G, Shanson D C, Farthing C, Lawrence A G, Tedder R S, Cheingsong-Popov R, Dalgleish A, Weiss R A
Lancet. 1984 Sep 1;2(8401):480-3. doi: 10.1016/s0140-6736(84)92563-7.
Between 1980 and 1984 28 homosexual men who had had ano-genital intercourse with patients with either acquired immunodeficiency syndrome (AIDS) or persistent generalised lymphadenopathy (PGL) were followed up. The pattern of the sexual links indicated that within this group there were two clusters, one consisting of 7 men and the other of 13.17 of the 28 contacts became ill with either AIDS or PGL; among those in the clusters, 4 died of AIDS and 11 had PGL, and of the rest 2 had PGL. 16 of the 19 men in the clusters who were tested for HTLV-III antibodies were seropositive, as were 7 of those not in the clusters. 111 men attending a genitourinary medicine clinic who had not had known contact with either AIDS or PGL patients and who were being screened for syphilis served as controls. Of these, 19/86 who were homosexual and 0/25 who were heterosexual were positive for HTLV-III antibodies. None of the 4 who died of AIDS had had contact with each other. The 2 in the first cluster seemed to have been linked by a symptomless HTLV-III-negative man, who was also probably the link between the two clusters, while in the second cluster the chief "carrier" seemed to be a seropositive man in whom PGL developed. These findings are consistent with the hypothesis that HTLV-III is the sexually transmitted causative agent of AIDS and PGL.
1980年至1984年间，对28名与获得性免疫缺陷综合征（艾滋病）或持续性全身性淋巴结病（PGL）患者有肛门生殖器性交的同性恋男子进行了随访。性接触模式表明，该组中有两个集群，一个由7名男子组成，另一个由13名男子组成。28名接触者中有17人患上了艾滋病或PGL；在集群中的那些人中，4人死于艾滋病且11人患有PGL，其余的2人患有PGL。在接受HTLV-III抗体检测的集群中的19名男子中，有16人呈血清阳性，不在集群中的人中有7人呈血清阳性。111名到泌尿生殖医学诊所就诊、此前未与艾滋病或PGL患者有过已知接触且正在接受梅毒筛查的男子作为对照。其中，86名同性恋者中有19人、25名异性恋者中有0人HTLV-III抗体呈阳性。死于艾滋病的4人彼此之间没有接触。第一个集群中的2人似乎是通过一名无症状的HTLV-III阴性男子联系起来的，该男子可能也是两个集群之间的联系纽带，而在第二个集群中，主要“携带者”似乎是一名血清阳性男子，他患上了PGL。这些发现与HTLV-III是艾滋病和PGL的性传播致病因子这一假设相符。
