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利用双光子活性溶剂化荧光探针破译内质网中的微观极性。

Deciphering micro-polarity inside the endoplasmic reticulum using a two-photon active solvatofluorochromic probe.

机构信息

Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhopal-462066, MP, India.

出版信息

Chem Commun (Camb). 2018 Sep 18;54(75):10590-10593. doi: 10.1039/c8cc03962c.

DOI:10.1039/c8cc03962c
PMID:30168820
Abstract

A new class of two-photon active and solvatofluorochromic dyes for the determination of ER polarity is reported. The fluorescent colour spans almost the entire visible spectrum. One of the derivatives is rationally designed for specific ER targeting. Finally, the fluorescence spectral scanning technique has been utilised to determine the micro-polarity inside the ER which is found to be much lower than that of water.

摘要

本文报道了一类新型的用于测定内质网极性的双光子活性和溶剂致变色荧光染料。这些荧光染料的颜色几乎覆盖了整个可见光谱。其中一种衍生物被合理设计用于特定的内质网靶向。最后,利用荧光光谱扫描技术测定内质网内部的微观极性,结果发现其极性远低于水。

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