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高频脊髓刺激(HF10-SCS)治疗神经源性膀胱失禁的回顾性病例系列研究。

A Retrospective Case Series of High-Frequency Spinal Cord Stimulation (HF10-SCS) in Neurogenic Bladder Incontinence.

机构信息

Department for Stereotaxy and Functional Neurosurgery, Center of Neurosurgery Cologne-Merheim Medical Center (CMMC), University of Witten/Herdecke, Cologne, Germany.

出版信息

Oper Neurosurg (Hagerstown). 2019 Jul 1;17(1):14-20. doi: 10.1093/ons/opy236.

Abstract

BACKGROUND

Current treatment options for bladder disorders of neurogenic etiology often leave unsatisfactory results. Therefore, new and effective treatments must be investigated. High-frequency spinal cord stimulation (HF-SCS) at 10 kHz has proven to be effective in the treatment of refractory chronic back and leg pain.

OBJECTIVE

To evaluate the efficacy of HF-SCS at 10 kHz in alleviating lower urinary tract dysfunction and bladder incontinence in 5 patients with underlying neurological disease or spinal cord injury, through retrospective study.

METHODS

Urodynamic parameters such as voiding frequency, residual volume, episodes of incontinence, and the patients' subjective impression impairment of life were assessed and compared pre- and postoperatively. Reduction in pain intensity was assessed as change on the Numeric Rating Scale (NRS).

RESULTS

All 5 patients had significantly positive outcomes. Episodes of leakage per day improved by 83% on average. Quality of life questionnaires and subjective bother scale revealed an improvement of 36% and 57%, respectively. Individual symptoms among the patient group such as residual volume also responded to the treatment as well. Mean pain NRS of 8.6 cm was reduced to 3.9 cm (55%) at 6 mo follow-up.

CONCLUSION

HF-SCS at 10 kHz significantly alleviated symptoms of neurogenic bladder incontinence in patients suffering from neurological disease or spinal cord injury. However, larger and prospective, randomized studies are necessary to make a clear statement regarding the efficacy of this therapy in lower urinary tract dysfunction and bladder incontinence.

摘要

背景

目前针对神经源性膀胱疾病的治疗选择往往效果不尽人意。因此,必须研究新的有效治疗方法。10 kHz 高频脊髓刺激(HF-SCS)已被证明对治疗难治性慢性腰背和腿部疼痛有效。

目的

通过回顾性研究,评估 10 kHz HF-SCS 治疗 5 例神经源性疾病或脊髓损伤患者下尿路功能障碍和膀胱失禁的疗效。

方法

评估术前和术后排尿频率、残余尿量、失禁发作次数以及患者生活质量受损的主观印象等尿动力学参数,并进行比较。疼痛强度的降低程度通过数字评分量表(NRS)的变化来评估。

结果

所有 5 例患者均有显著的积极结果。平均每天漏尿次数减少了 83%。生活质量问卷和主观困扰量表分别显示改善了 36%和 57%。患者组的个体症状(如残余尿量)也对治疗有反应。平均疼痛 NRS 从 8.6 cm 降低到 6 个月随访时的 3.9 cm(55%)。

结论

10 kHz HF-SCS 显著缓解了患有神经源性疾病或脊髓损伤的患者的膀胱失禁症状。然而,需要更大规模和前瞻性、随机研究来明确这种治疗方法对下尿路功能障碍和膀胱失禁的疗效。

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