Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, PI, Brazil.
Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, PI, Brazil.
Life Sci. 2018 Oct 1;210:55-64. doi: 10.1016/j.lfs.2018.08.053. Epub 2018 Aug 28.
Actually, arterial hypertension is a major public health concern, which involves the renin angiotensin aldosterone system (RAS), via activation of the angiotensin receptors AT and AT of the cardiovascular system. Although angiotensin is an important stimulant of the gut permeability to sodium and water, little is known about the effects of arterial hypertension on gut motor behavior. Thus, we evaluated in rats the effect of hypertension induced by two-kidney one-clip (2K1C) model on the gastric motility, as well as the influence of exercise and RAS blockers treatment in such phenomenon. One week after surgery the rats were treated with Aliskiren (50 mg·kg, p.o.), Captopril (50 mg·kg, p.o.) or Losartan (10 mg·kg, p.o). Other group of rats was submitted to swimming with 5% body weight overload. After 4 weeks of physical training or pharmacological treatment, we assessed the gastric retention in all groups (GR) of a liquid test meal, the mean arterial pressure (MAP), the heart rate (HR) and the HR variation (HRV) as well as the in vitro contractility of gastric fundus. Renovascular hypertension increased (p < 0.05) the GR, MAP and HR, a phenomenon prevented by pretreatment with RAS blockers or exercise. The two kidney one-clip Hypertension (2K1C) decreased (p < 0.05) the gastric fundus responsiveness, a phenomenon also prevented by exercise. It conclusion, renovascular hypertension delays the gastric emptying of liquids, a phenomenon involving the activation of RAS, where exercise or blockade with aliskiren, captopril and losartan prevent gastric dysmotility.
实际上，动脉高血压是一个主要的公共卫生关注点，涉及肾素血管紧张素醛固酮系统（RAS），通过激活心血管系统的血管紧张素受体 AT 和 AT。虽然血管紧张素是刺激肠道对钠和水通透性的重要物质，但对于动脉高血压对肠道运动行为的影响知之甚少。因此，我们在大鼠中评估了由双肾一夹（2K1C）模型引起的高血压对胃动力的影响，以及运动和 RAS 阻滞剂治疗对这种现象的影响。手术后一周，大鼠用阿利克仑（50mg·kg，po）、卡托普利（50mg·kg，po）或氯沙坦（10mg·kg，po）治疗。另一组大鼠进行 5%体重过载游泳。经过 4 周的体能训练或药物治疗后，我们评估了所有组（GR）液体试验餐的胃潴留、平均动脉压（MAP）、心率（HR）和心率变异性（HRV）以及胃底的离体收缩性。肾血管性高血压增加（p<0.05）GR、MAP 和 HR，这一现象可通过 RAS 阻滞剂或运动预处理来预防。两肾一夹高血压（2K1C）降低（p<0.05）胃底反应性，这一现象也可通过运动来预防。结论，肾血管性高血压延迟了液体的排空，这一现象涉及 RAS 的激活，运动或用阿利克仑、卡托普利和氯沙坦进行阻滞可预防胃动力障碍。
