Beller F K, Nienhaus H, Niedner W, Holzgreve W
Am J Obstet Gynecol. 1986 Aug;155(2):247-55. doi: 10.1016/0002-9378(86)90799-4.
The risk of developing cancer in the contralateral breast is five to seven times the risk of cancer occurrence for the normal female population. In patients in 365 consecutive operations, 15 frankly invasive cancers and four metastatic lesions were found in the contralateral breast as well as an additional 28 lesions in situ, totaling 13%. An additional 30% of the patients had severe dysplasia with an unknown potential for becoming cancerous. Only less than one third of the cancers in the contralateral breast were symptomatic (by palpation or mammography or both) but not recognized at the time of primary treatment. The majority of lesions in the contralateral breast are due to a second primary growth, and only a minority is metastatic. The results of 203 bilateral operations consisting of a modified subcutaneous mastectomy with axillary lymph node dissection and radiation are presented; this cosmetically acceptable procedure reduces the number of cancers in the contralateral breast to an incidence of 1% to 2%.
对侧乳房发生癌症的风险是正常女性人群患癌风险的五到七倍。在连续365例手术患者中，对侧乳房发现15例明显浸润性癌和4例转移灶，另有28例原位病变，共计13%。另外30%的患者有严重发育异常，其癌变可能性未知。对侧乳房中只有不到三分之一的癌症有症状（通过触诊或乳房X线摄影或两者兼有），但在初次治疗时未被识别。对侧乳房的大多数病变是由于第二原发性肿瘤生长，只有少数是转移性的。本文介绍了203例双侧手术的结果，这些手术包括改良皮下乳房切除术加腋窝淋巴结清扫和放疗；这种在美容上可接受的手术将对侧乳房癌症的发生率降低到1%至2%。
