Korobkova T P, Singal E M, Ivanitskaia L P, Kudinova M K, Karbyshev V D
Antibiot Med Biotekhnol. 1986 Jun;31(6):428-31.
A culture of Streptomyces sp., producing an antibiotic named galtamycin was isolated from a soil sample collected in the Gorno-Altai Autonomous Region. The antibiotic belongs to anthracyclines. Biosynthesis, isolation, physico-chemical and biological properties of the antibiotic are described. The studies showed that galtamycin consisting of a chromophore and three unidentified sugars is a new compound differing from the known anthracyclines except trypanomycin by the absence of the UV absorption maximum at 230-240 nm. Galtamycin differs from trypanomycin by the molecular weight of the chromophore. Galtamycin showed low antitumor activity and was inactive against grampositive and gramnegative organisms and fungi.
从戈尔诺-阿尔泰自治区采集的土壤样本中分离出一种链霉菌属菌株,该菌株能产生一种名为加尔他霉素的抗生素。这种抗生素属于蒽环类。文中描述了该抗生素的生物合成、分离、物理化学及生物学特性。研究表明,加尔他霉素由一个发色团和三种未知糖组成,是一种新化合物,与已知的蒽环类抗生素不同,除曲帕霉素外,它在230 - 240 nm处没有最大紫外吸收。加尔他霉素与曲帕霉素在发色团分子量上有所不同。加尔他霉素显示出低抗肿瘤活性,对革兰氏阳性菌、革兰氏阴性菌和真菌均无活性。