Department of Molecular Medicine & Pathology, School of Medical Sciences, Faculty of Medical & Health Sciences, The University of Auckland, Private Bag 921019, Auckland 1142, New Zealand.
Department of Molecular Medicine & Pathology, School of Medical Sciences, Faculty of Medical & Health Sciences, The University of Auckland, Private Bag 921019, Auckland 1142, New Zealand.
Semin Cell Dev Biol. 2019 Jul;91:86-93. doi: 10.1016/j.semcdb.2018.08.016. Epub 2018 Sep 1.
The intermediate mesoderm is located between the somites and the lateral plate mesoderm and gives rise to renal progenitors that contribute to the three mammalian kidney types (pronephros, mesonephros and metanephros). In this review, focusing largely on murine kidney development, we examine how the intermediate mesoderm forms during gastrulation/axis elongation and how it progressively gives rise to distinct renal progenitors along the rostro-caudal axis. We highlight some of the potential signalling cues and core transcription factor circuits that direct these processes, up to the point of early metanephric kidney formation.
中胚层位于体节和侧板中胚层之间，产生肾祖细胞，这些祖细胞有助于形成三种哺乳动物肾脏类型（前肾、中肾和后肾）。在这篇综述中，我们主要关注小鼠肾脏发育，研究中胚层在原肠胚形成/轴伸长过程中是如何形成的，以及它如何沿着头尾部轴逐步产生不同的肾祖细胞。我们强调了一些潜在的信号线索和核心转录因子回路，这些线索和回路指导着这些过程，直到早期后肾形成。
