Klein E, Ward R A, Harding G B
Artif Organs. 1986 Jun;10(3):248-50. doi: 10.1111/j.1525-1594.1986.tb02554.x.
Calcium carbonate has been observed to precipitate in the fluid pathway of dialysate delivery systems dispensing bicarbonate-containing dialysates. Such precipitation can occlude the fluid pathway, leading to system malfunction and increased maintenance requirements. We show that commercial supplies of sodium bicarbonate are contaminated by trace amounts of sodium carbonate. This contamination may result in immediate precipitation of calcium carbonate on formulation of the dialysate, since bicarbonate-containing dialysates, as formulated, are metastable with respect to calcium carbonate. Sparging of the bicarbonate-containing concentrate with carbon dioxide converts any carbonate to bicarbonate, thus avoiding the formation of precipitates on addition of calcium ions.
已观察到碳酸钙会在分配含碳酸氢盐透析液的透析液输送系统的流体通道中沉淀。这种沉淀会堵塞流体通道，导致系统故障并增加维护需求。我们发现，市售的碳酸氢钠被痕量碳酸钠污染。这种污染可能导致在配制透析液时碳酸钙立即沉淀，因为配制好的含碳酸氢盐透析液相对于碳酸钙是亚稳的。用二氧化碳鼓泡含碳酸氢盐的浓缩液可将任何碳酸盐转化为碳酸氢盐，从而避免在添加钙离子时形成沉淀。
