碳酸氢钠、碳酸钠以及碳酸氢钠/碳酸钠混合物对密闭系统中血液PCO2的影响。
Effects of sodium bicarbonate, disodium carbonate, and a sodium bicarbonate/carbonate mixture on the PCO2 of blood in a closed system.
作者信息
Shapiro J I, Elkins N, Logan J, Ferstenberg L B, Repine J E
机构信息
Webb-Waring Institute for Biomedical Research, Department of Medicine, University of Colorado Health Sciences Center, Denver, USA.
出版信息
J Lab Clin Med. 1995 Jul;126(1):65-9.
The effects of adding Carbicarb--a 50:50 mixture of sodium bicarbonate (NaHCO3) and sodium carbonate (Na2CO3)--or sodium bicarbonate or disodium carbonate individually to whole blood were examined in vitro. Adding HCl to blood in an open system rapidly decreased the pH and [HCO3-] without increasing partial pressure of carbon dioxide (PCO2), whereas adding HCl to blood in a closed system markedly decreased pH and increased PCO2. Adding sodium bicarbonate to blood caused a rapid and predictable increase in PCO2 that was linearly related to the pH of the blood at the time of addition. Adding disodium carbonate to blood caused a rapid and predictable fall in PCO2 that was linearly related to the initial PCO2 of the blood at the time of addition. Adding Carbicarb to blood caused relatively little change in PCO2 over a wide range of initial pH and PCO2 values.
在体外研究了向全血中分别添加卡比卡（碳酸氢钠（NaHCO₃）和碳酸钠（Na₂CO₃）的50:50混合物）、碳酸氢钠或碳酸钠的效果。在开放系统中向血液中添加盐酸会迅速降低pH值和[HCO₃⁻]，而不会增加二氧化碳分压（PCO₂），而在封闭系统中向血液中添加盐酸会显著降低pH值并增加PCO₂。向血液中添加碳酸氢钠会导致PCO₂迅速且可预测地增加，这与添加时血液的pH值呈线性相关。向血液中添加碳酸钠会导致PCO₂迅速且可预测地下降，这与添加时血液的初始PCO₂呈线性相关。在广泛的初始pH值和PCO₂值范围内，向血液中添加卡比卡导致PCO₂变化相对较小。
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