Baracz Sarah J, Everett Nicholas A, Cornish Jennifer L
Department of Psychology, Macquarie University, North Ryde, NSW, 2109, Australia.
Department of Psychology, Macquarie University, North Ryde, NSW, 2109, Australia.
Neurosci Biobehav Rev. 2020 Mar;110:114-132. doi: 10.1016/j.neubiorev.2018.08.014. Epub 2018 Aug 30.
Early life trauma is strongly associated with an increased vulnerability to abuse illicit drugs and the impairment of neural development. This includes alterations to the development of the oxytocin system, which plays a pivotal role in the regulation of social behaviours and emotion. Dysregulation of this important system also contributes to increased susceptibility to develop drug addiction. In this review, we provide an overview of the animal models of early life stress that are widely used, and discuss the impact that early life stress has on drug-taking behaviour in adolescence and adulthood in both sexes. We link this to the changes that early life stress has on the endogenous oxytocin system, and how exogenously administered oxytocin may help to re-establish functioning of the system, and in turn, reduce drug-taking behaviour.
早期生活创伤与滥用非法药物的易感性增加以及神经发育受损密切相关。这包括催产素系统发育的改变，该系统在社会行为和情绪调节中起关键作用。这个重要系统的失调也会导致对药物成瘾的易感性增加。在这篇综述中，我们概述了广泛使用的早期生活应激动物模型，并讨论了早期生活应激对青春期和成年期两性药物使用行为的影响。我们将此与早期生活应激对内源性催产素系统的变化联系起来，以及外源性给予催产素如何有助于重新建立该系统的功能，进而减少药物使用行为。
