表皮生长因子受体（EGFR）、人表皮生长因子受体2（HER2）和人表皮生长因子受体3（HER3）在基底细胞癌侵袭性中的作用。

The involvement of EGFR, HER2 and HER3 in the basal cell carcinomas aggressiveness.

作者信息

Florescu Diana Elena, Stepan Alex Emilian, Mărgăritescu Claudiu, Ciurea Raluca Niculina, Stepan Mioara Desdemona, Simionescu Cristiana Eugenia

机构信息

Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;

出版信息

Rom J Morphol Embryol. 2018;59(2):479-484.

PMID:30173251

Abstract

Basal cell carcinomas (BCCs) are the most common malignant skin tumors, with variable prognosis and recurrence rates, depending on histopathological subtypes. The study analyzed the immunoexpression of epidermal growth factor receptors (EGFRs) in 53 cases of nodular, adenoid and morpheaform BCCs in relation to clinico-pathological associated parameters. We found significant differences in the expression of EGFR, HER2 and HER3 reported to histological BCC types. The nodular type presented the weakest expression of EGFRs, while the morpheaform type had a high expression of all receptors and the adenoid type an increased expression only in case of EGFR and HER2. This study supports the involvement of EGFR, HER2 and HER3 in BCC aggressiveness of and in tumor differentiating towards different histological subtypes.

摘要

基底细胞癌（BCCs）是最常见的恶性皮肤肿瘤，其预后和复发率各不相同，这取决于组织病理学亚型。该研究分析了53例结节状、腺样和硬斑病样基底细胞癌中表皮生长因子受体（EGFRs）的免疫表达情况，并将其与临床病理相关参数进行关联分析。我们发现，EGFR、HER2和HER3的表达在不同组织学类型的基底细胞癌中存在显著差异。结节状类型的EGFRs表达最弱，而硬斑病样类型的所有受体均高表达，腺样类型仅在EGFR和HER2表达增加。本研究支持EGFR、HER2和HER3参与基底细胞癌的侵袭性以及肿瘤向不同组织学亚型的分化过程。