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免疫组织化学在滑膜肉瘤诊断和治疗中的作用。

The role of immunohistochemistry in the diagnosis and management of synovial sarcoma.

作者信息

Pop Daniel Laurenţiu, Folescu Roxana, Deleanu Bogdan Nicolae, Iacob Mihaela, Vermeşan Dinu, Prejbeanu Radu, Maliţa Daniel Claudiu, Hărăguş Horia George, Ciupe Bogdan Cătălin, Zamfir Carmen Lăcrămioara, Nodiţi Gheorghe

机构信息

Department of Anatomy and Embryology, Department of Medical Radiology and Imagistics, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

出版信息

Rom J Morphol Embryol. 2018;59(2):569-572.

PMID:30173264
Abstract

Synovial sarcoma (SS) is a malignant soft tissue tumor representing 5-10% of all soft tissue sarcomas. Most synovial sarcomas are found at the extremities, especially in the lower limbs. A 28-year-old female presented at the Department of Plastic and Reconstructive Surgery, "Dr. Pius Brînzeu" Clinical Hospital, Timişoara, Romania, for evaluation of a mass located in the anterior region of the elbow. Imagistic, histological and immunohistochemically evaluations established the diagnosis of monophasic spindle cell SS G2. Block excision of the tumor with oncological safety margins was performed followed by total elbow arthroplasty. The patient then received radio- and chemotherapy. The case was followed-up at regular intervals for local recurrence and metastases and was free of symptoms at two years. Early diagnosis of SS, multimodal therapies and performing an arthroplasty of the elbow allowed the patient to resume daily activities. The unpredictable evolution requires regular follow-up for a long period of time.

摘要

滑膜肉瘤(SS)是一种恶性软组织肿瘤,占所有软组织肉瘤的5%-10%。大多数滑膜肉瘤发生于四肢,尤其是下肢。一名28岁女性因肘部前方肿物前往罗马尼亚蒂米什瓦拉“皮乌斯·布林泽乌医生”临床医院整形与重建外科就诊。影像学、组织学和免疫组化评估确诊为单相梭形细胞SS G2。在保证肿瘤学安全切缘的情况下对肿瘤进行整块切除,随后进行全肘关节置换术。患者随后接受了放疗和化疗。对该病例定期随访局部复发和转移情况,两年时无症状。滑膜肉瘤的早期诊断、多模式治疗以及肘关节置换术使患者能够恢复日常活动。其不可预测的病程发展需要长期定期随访。

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