Migacz Ewa, Howard David, Gajewski Zdzisław, Siewruk Katarzyna, Kukwa Wojciech
Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, 19/25 Stepinska Street, 00-739, Warsaw, Poland.
Royal National Throat, Nose and Ear Hospital, 330 Gray's Inn Road, London, UK.
Eur Arch Otorhinolaryngol. 2018 Nov;275(11):2813-2816. doi: 10.1007/s00405-018-5112-3. Epub 2018 Sep 1.
This is a feasibility study of functional identification of the abductor and adductor recurrent laryngeal nerve branches, which could be used in the donor's larynx for functional laryngeal transplantation.
The study was performed on swine (n = 3) and human (n = 4) models of a donor larynx. The recurrent laryngeal nerve and its branches were found. Using stimulator, abductor and adductor branches were identified, and glottis closing and opening were captured with an endoscope.
The result was positive if two ENT specialists noticed at least one adduction and one abduction movement in the same subject. It was obtained in three out of three swine and three out of four humans.
This study shows a way of reinnervation of a transplanted larynx which might result in a functional organ. It describes the first step of the procedure: functional identification of the abductor and adductor branches of the recurrent laryngeal nerve in the donor before the larynx is excised for transplantation.
这是一项关于喉返神经外展支和内收支功能识别的可行性研究，该研究可用于供体喉部的功能性喉移植。
该研究在供体喉部的猪模型（n = 3）和人类模型（n = 4）上进行。找到喉返神经及其分支。使用刺激器识别外展支和内收支，并用内窥镜捕捉声门的闭合和张开。
如果两名耳鼻喉科专家在同一受试者中至少观察到一次内收运动和一次外展运动，则结果为阳性。三只猪中的三只以及四个人中的三个获得了阳性结果。
本研究展示了一种对移植喉进行再神经支配的方法，这可能会产生一个功能正常的器官。它描述了该手术的第一步：在切除喉部进行移植之前，对供体喉返神经的外展支和内收支进行功能识别。
