a Department of Orthopaedic Surgery , Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.
b Department of Orthopedic Surgery , Seoul National University College of Medicine, Seoul National University Bundang Hospital , Seoul , Korea.
Connect Tissue Res. 2019 Jan;60(1):21-28. doi: 10.1080/03008207.2018.1517759. Epub 2018 Sep 20.
Large joint arthrofibrosis and scarring, involving the shoulder, elbow, hip, and knee, can result in the loss of function and immobility. The pathway of joint contracture formation is still being elucidated and is due to aberrations in collagen synthesis and misorientation of collagen fibrils. Novel antibodies are being developed to prevent arthrofibrosis, and current treatment methods for arthrofibrosis include medical, physical, and surgical treatments. This article describes the biology of joint contracture formation, along with current and future pharmacologic, biologic, and medical interventions.
大关节纤维性关节僵硬和瘢痕形成，涉及肩部、肘部、臀部和膝盖，可导致功能丧失和活动受限。关节挛缩形成的途径仍在阐明，这是由于胶原蛋白合成异常和胶原蛋白纤维的错位。新型抗体正在开发中以预防纤维性关节僵硬，目前纤维性关节僵硬的治疗方法包括药物、物理和手术治疗。本文描述了关节挛缩形成的生物学特性，以及当前和未来的药物、生物和医疗干预措施。
