高龄患者冠状动脉支架置入术后支架内再闭塞的潜在预后、诊断和治疗标志物。
Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After Coronary Stenting.
机构信息
Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.
出版信息
Curr Pharm Des. 2018;24(28):3359-3365. doi: 10.2174/1381612824666180830141918.
BACKGROUND
Oxidative stress and inflammatory response played important roles in advanced atherosclerosis. We tried to confirm clinical diagnostic significance of the assessments of oxidative stress and inflammatory response status with in-stent reocclusion in 283 advanced age patients (80～90 years) after coronary stenting.
METHODS
We analyzed levels of circulating superoxide dismutase 3 (SOD3), nitric oxide (NO), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), acrolein（ACR）, and paraoxonase-1 （PON-1）in advanced age patients with in-stent restenosis and reocclusion after coronary stenting.
RESULTS
Levels of SOD3, eNOS, NO and PON-1 were lowered (P<0.001) and levels of MDA and ACR were increased (P<0.001).
CONCLUSION
The assessments of the biomarkers of oxidative stress and inflammatory response (levels of MDA and ACR) and anti-oxidant biomarkers (levels of eNOS, NO, SOD3 and PON-1) could be considered as potential prognostic and diagnostic indicators of in-stent reocclusion in advanced age patients after coronary stenting.
背景
氧化应激和炎症反应在晚期动脉粥样硬化中起着重要作用。我们试图通过对 283 名高龄（80-90 岁）经冠状动脉支架置入术后发生支架内再闭塞的患者进行氧化应激和炎症反应状态评估，以确认其临床诊断意义。
方法
我们分析了支架内再狭窄和再闭塞的高龄患者循环中超氧化物歧化酶 3（SOD3）、一氧化氮（NO）、内皮型一氧化氮合酶（eNOS）、丙二醛（MDA）、丙烯醛（ACR）和对氧磷酶-1（PON-1）的水平。
结果
SOD3、eNOS、NO 和 PON-1 水平降低（P<0.001），MDA 和 ACR 水平升高（P<0.001）。
结论
氧化应激和炎症反应（MDA 和 ACR 水平）以及抗氧化生物标志物（eNOS、NO、SOD3 和 PON-1 水平）的生物标志物评估可被视为冠状动脉支架置入术后高龄患者支架内再闭塞的潜在预后和诊断指标。
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