Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, China.
Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, China.
Cytokine. 2020 May;129:155028. doi: 10.1016/j.cyto.2020.155028. Epub 2020 Feb 7.
The inflammation responses and oxidative stress were closely associated with coronary heart disease. We tried to evaluate the effects of multiple stents, long stents and small-diameter stents on inflammation responses and oxidative stress in the elderly patients with long diffuse reocclusions.
The blood samples were obtained after an overnight fast and we evaluated the expression levels of soluble ST2 (sST2), acrolein (ACR), aldosterone (ALD), angiotensin II (Ang II), toll-like receptor 4 (TLR4), tumour necrosis factor-α (TNF-α), malondialdehyde (MDA) and high sensitivity C-reactive protein (hs-CRP) in the elderly patients with long diffuse reocclusions after multiple stents, long stents, small-diameter stents implanted.
Levels of sST2, ACR, ALD, Ang II, TLR4, TNF-α, MDA and hs-CRP were remarkably increased (P < 0.001) in the elderly patients with long diffuse reocclusions after multiple stents, long stents, small-diameter stents implanted. The multiple stents, long stents and small-diameter stents may promote inflammatory response and oxidative stress, and led to long diffuse reocclusions in the elderly patients. The multiple stents, long stents and small-diameter stents may play the key roles in long diffuse reocclusions of the elderly patients.
The inflammatory and oxidative stress biomarkers could be considered as potential non-invasive diagnostic, predictive, prognostic and therapeutic molecular biomarkers for long diffuse reocclusions in the elderly patients after implantations of multiple stents, long stents and small-diameter stents.
炎症反应和氧化应激与冠心病密切相关。我们试图评估在长弥漫性再闭塞的老年患者中，使用多个支架、长支架和小直径支架对炎症反应和氧化应激的影响。
在隔夜禁食后采集血液样本，并评估长弥漫性再闭塞老年患者植入多个支架、长支架和小直径支架后可溶性 ST2（sST2）、丙烯醛（ACR）、醛固酮（ALD）、血管紧张素 II（Ang II）、Toll 样受体 4（TLR4）、肿瘤坏死因子-α（TNF-α）、丙二醛（MDA）和高敏 C 反应蛋白（hs-CRP）的表达水平。
植入多个支架、长支架和小直径支架后，长弥漫性再闭塞老年患者的 sST2、ACR、ALD、Ang II、TLR4、TNF-α、MDA 和 hs-CRP 水平显著升高（P<0.001）。多个支架、长支架和小直径支架可能会促进炎症反应和氧化应激，导致老年患者长弥漫性再闭塞。多个支架、长支架和小直径支架可能在老年患者长弥漫性再闭塞中起关键作用。
炎症和氧化应激生物标志物可作为潜在的非侵入性诊断、预测、预后和治疗分子标志物，用于评估植入多个支架、长支架和小直径支架后老年患者的长弥漫性再闭塞。
