天然化学物质是否与当前用于体重管理的药物治疗的相同靶点相互作用？——综述。

Do the Natural Chemical Compounds Interact with the Same Targets of Current Pharmacotherapy for Weight Management?-A Review.

机构信息

School of Health and Biomedical Sciences, RMIT University, Bundoora West Campus, Victoria 3083, Australia.

School of Sciences, RMIT University, Bundoora West Campus, Victoria 3083, Australia.

出版信息

Curr Drug Targets. 2019;20(4):399-411. doi: 10.2174/1389450119666180830125958.

DOI:10.2174/1389450119666180830125958

PMID:30173643

Abstract

BACKGROUND

Obesity has become a worldwide health concern. Pharmacotherapies are now being introduced because lifestyle modifications alone are insufficient for weight management. The treatment outcomes of current approved anti-obesity agents are not satisfying due to drug-related intolerances. And so natural therapies including herbal medicines are popular alternatives for weight reduction; however, there are limited studies about their mechanism of actions.

METHODS

Five databases (PubMed, Scopus, Google Scholar, Science Direct, Proquest) were searched to investigate the targets and safety profiles of the current and past anti-obesity drugs that have been approved by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA) as well as the commonly used off-label agents. The targets for weight-loss natural products and their principle bioactive components have also been searched. Only articles in English were included.

RESULTS

The targets for current anti-obesity single agents include pancreatic lipase, Glucagon Like Peptide-1(GLP-1) receptor, and serotonin 2C (5-HT2C) receptor. Potential targets such as amylin, pancreatic alpha amylase, leptin receptor, melanocortin receptor 4 receptor (MC4R), Peroxisome Proliferator- Activated Receptors gamma (PPAR γ), endocannabinoid 1 (CB1) receptor and Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) were discussed in various studies. Natural compounds have been found to interact with targets like pancreatic lipase, pancreatic alpha amylase, AMPK and PPAR γ to achieve weight reduction.

CONCLUSION

Current pharmacotherapies and natural chemical compounds do act on same targets. Further investigations on the interactions between herbal compounds and the above targets are essential for the development of novel weight-loss therapies.

摘要

背景

肥胖已成为全球关注的健康问题。由于生活方式的改变不足以进行体重管理，因此现在引入了药物疗法。由于与药物相关的不耐受，目前批准的抗肥胖药物的治疗效果并不令人满意。因此，包括草药在内的天然疗法是减肥的热门替代品；然而，关于它们的作用机制的研究有限。

方法

在五个数据库（PubMed、Scopus、Google Scholar、Science Direct、Proquest）中搜索了当前和过去已被美国食品和药物管理局（FDA）或欧洲药品管理局（EMA）批准的抗肥胖药物以及常用的非标签药物的靶点和安全性概况。还搜索了减肥天然产品的靶点及其主要生物活性成分。仅包括英文文章。

结果

目前的抗肥胖单药靶点包括胰脂肪酶、胰高血糖素样肽-1（GLP-1）受体和 5-羟色胺 2C（5-HT2C）受体。各种研究中还讨论了潜在的靶点，如胰岛淀粉样多肽、胰α淀粉酶、瘦素受体、黑皮质素受体 4 受体（MC4R）、过氧化物酶体增殖物激活受体 γ（PPAR γ）、内源性大麻素 1（CB1）受体和腺苷一磷酸（AMP）激活蛋白激酶（AMPK）。已发现天然化合物与胰脂肪酶、胰α淀粉酶、AMPK 和 PPAR γ等靶点相互作用，从而达到减肥的效果。