Maruthanila V Lenin, Elancheran Ramakrishnan, Kunnumakkar Ajaikumar B, Kabilan Senthamaraikannan, Kotoky Jibon
Division of Life Sciences, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, India.
Department of Chemistry, Gauhati University, Guwahati-781014, Assam, India.
Anticancer Agents Med Chem. 2018;18(14):1983-1990. doi: 10.2174/1871520618666180830151720.
Emerging evidence present credible support in favour of the potential role of mahanine and girinimbine. Non-toxic herbal carbazole alkaloids occur in the edible part of and . Mahanine and girinimbine are the major potent compounds from these species. In fact, they interfered with tumour expansion and metastasis development through down-regulation of apoptotic and antiapoptotic protein, also involved in the stimulation of cell cycle arrest. Consequently, these compounds were well proven for the and evaluation that could be developed as novel agents either alone or as an adjuvant to conventional therapeutics. Therefore, mahanine and girinimbine analogs have the potential to be the promising chemopreventive agents for the tumour recurrence and the treatment of human malignancies. In this review, an updated wide-range of pleiotropic anticancer and biological effects induction by mahanine and girinimbine against cancer cells were deeply summarized.
新出现的证据为马汉宁和吉里宁的潜在作用提供了可靠支持。无毒的草药咔唑生物碱存在于[具体植物1]和[具体植物2]的可食用部分。马汉宁和吉里宁是这些植物中的主要活性化合物。事实上，它们通过下调凋亡蛋白和抗凋亡蛋白干扰肿瘤扩展和转移发展，还参与刺激细胞周期停滞。因此，这些化合物在[具体评估1]和[具体评估2]中得到充分验证，可单独或作为传统疗法的辅助药物开发为新型药物。所以，马汉宁和吉里宁类似物有可能成为治疗肿瘤复发和人类恶性肿瘤的有前景的化学预防剂。在本综述中，深入总结了马汉宁和吉里宁对癌细胞诱导的广泛多效抗癌和生物学效应的最新情况。
