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原阿片碱型生物碱对γ-氨基丁酸受体结合的增强作用。

Enhancement of gamma-aminobutyric acid receptor binding by protopine-type alkaloids.

作者信息

Kardos J, Blaskó G, Simonyi M

出版信息

Arzneimittelforschung. 1986 Jun;36(6):939-40.

PMID:3017370
Abstract

Protopine, cryptopine and allocryptopine were demonstrated to enhance 3H-gamma-aminobutyric acid (3H-GABA) binding to rat brain synaptic membrane receptors. The above finding might be indicative of benzodiazepine-like activity of these alkaloids.

摘要

原阿片碱、隐品碱和别隐品碱被证实可增强3H-γ-氨基丁酸（3H-GABA）与大鼠脑突触膜受体的结合。上述发现可能表明这些生物碱具有类似苯二氮䓬的活性。

相似文献

1
Enhancement of gamma-aminobutyric acid receptor binding by protopine-type alkaloids.原阿片碱型生物碱对γ-氨基丁酸受体结合的增强作用。
Arzneimittelforschung. 1986 Jun;36(6):939-40.
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Group-selective reagent modification of the benzodiazepine-gamma-aminobutyric acid receptor-ionophore complex reveals that low-affinity gamma-aminobutyric acid receptors stimulate benzodiazepine binding.苯二氮䓬-γ-氨基丁酸受体-离子载体复合物的基团选择性试剂修饰表明，低亲和力的γ-氨基丁酸受体刺激苯二氮䓬结合。
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