活疫苗诱发的钩端螺旋体减毒异源保护作用。
Heterologous protection elicited by a live, attenuated, Leptospira vaccine.
机构信息
Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Melioidosis Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
出版信息
Vet Microbiol. 2018 Sep;223:47-50. doi: 10.1016/j.vetmic.2018.07.018. Epub 2018 Jul 21.
A previously-described live, attenuated vaccine (M1352, serovar Manilae, serogroup Pyrogenes) was tested in the hamster model of infection for cross-protective immunity. The vaccine elicited strong, significant cross-protection against lethal infection by strains representing four serologically distinct leptospiral serovars (Grippotyphosa, Australis, Canicola, and Autumnalis). Combined with our previously reported protection against serovars Pomona and Manilae, this work demonstrates unequivocal proof of concept for cross-protective immunity in leptospirosis.
先前描述的一种减毒活疫苗（M1352，马尼拉血清型，波杰亚血清群）已在仓鼠感染模型中进行了交叉保护免疫的测试。该疫苗对代表四个血清学上不同的钩端螺旋体血清型（Grippotyphosa、Australis、Canicola 和 Autumnalis）的菌株引起的致死性感染产生了强烈且显著的交叉保护作用。结合我们之前报道的对波摩那血清型和马尼拉血清型的保护作用，这项工作明确证明了钩端螺旋体病的交叉保护免疫的概念。
Zotero 插件