Bouvet J, Lemaitre L, Cariou C, Scotto M, Blain C, Oberli F, Cupillard L, Guigal P M
Boehringer Ingelheim Animal Health, Centre de Recherche de Saint-Vulbas, Parc Industriel de la Plaine de l'Ain, 805 Allée des Cyprès, 01150 Saint-Vulbas, France.
Boehringer Ingelheim Animal Health, Centre de Recherche de Saint-Vulbas, Parc Industriel de la Plaine de l'Ain, 805 Allée des Cyprès, 01150 Saint-Vulbas, France.
Vet Immunol Immunopathol. 2020 Jan;219:109985. doi: 10.1016/j.vetimm.2019.109985. Epub 2019 Nov 15.
Efficacy of the Leptospira components of multivalent vaccine DAPPi-L was previously demonstrated against virulent challenge with three serovars of Leptospira interrogans (Canicola, Icterohaemorrhagiae and Grippotyphosa) carried out 14 days after primary vaccination. In this study we demonstrate that this vaccine provides, two weeks after vaccination, an additional protection (prevention of mortality, clinical signs, renal infection, bacterial excretion, renal carriage and renal lesions) against fatal leptospirosis due to Leptospira interrogans serovar Copenhageni (serovar of major medical importance).
多价疫苗DAPPi-L中钩端螺旋体成分的有效性先前已在初次接种疫苗14天后针对用问号钩端螺旋体的三个血清型（犬型、出血性黄疸型和波摩那型）进行的强毒攻击得到证实。在本研究中，我们证明该疫苗在接种疫苗两周后，可针对由问号钩端螺旋体哥本哈根血清型（具有主要医学重要性的血清型）引起的致命钩端螺旋体病提供额外保护（预防死亡、临床症状、肾脏感染、细菌排泄、肾脏携带和肾脏病变）。
