Cho H J, Jericho K W
Can J Vet Res. 1986 Jan;50(1):27-31.
Immunity against pneumonic pasteurellosis was studied in calves after recovery from experimental respiratory disease with Pasteurella haemolytica. Nine calves were exposed to aerosols of parainfluenza-3 virus and Pasteurella haemolytica A1 six days apart to produce respiratory disease. After recovery from the disease, these nine principal and four control calves were challenged with aerosols of bovine herpesvirus 1 and P. haemolytica A1 four days apart. With this viral-bacterial challenge, the nine principal animals failed to develop clinical responses to this bacterial challenge and their lungs did not show the growth of P. haemolytica on cultures, whereas two of four control calves had elevated temperatures and developed necropurulent pneumonia with the isolation of P. haemolytica from the lungs. The principal calves had developed high levels of cytotoxin neutralizing antibodies in their sera following parainfluenza-3 virus-P. haemolytica infection. This demonstrated that immunity against pneumonic pasteurellosis can be achieved, with a suggestion that further search for an effective vaccine for P. haemolytica is warranted.
对从实验性溶血性巴氏杆菌呼吸道疾病中康复后的犊牛针对肺炎巴氏杆菌病的免疫力进行了研究。9头犊牛每隔6天暴露于副流感3病毒和气溶血性巴氏杆菌A1的气溶胶中，以引发呼吸道疾病。从疾病中康复后，这9头主要犊牛和4头对照犊牛每隔4天接受牛疱疹病毒1和气溶血性巴氏杆菌A1的气溶胶攻击。通过这种病毒-细菌攻击，9头主要动物对这种细菌攻击未产生临床反应，其肺部在培养物中未显示出气溶血性巴氏杆菌的生长，而4头对照犊牛中有2头体温升高，并发展为坏死性脓性肺炎，且从肺部分离出气溶血性巴氏杆菌。主要犊牛在副流感3病毒-气溶血性巴氏杆菌感染后，其血清中产生了高水平的细胞毒素中和抗体。这表明可以获得针对肺炎巴氏杆菌病的免疫力，提示有必要进一步寻找有效的气溶血性巴氏杆菌疫苗。
