以过氧化氢为终端氧化剂的手性钙催化不对称环氧化反应
Chiral Calcium-Catalyzed Asymmetric Epoxidation Reactions Using Hydrogen Peroxide as the Terminal Oxidant.
作者信息
Yamashita Yasuhiro, Macor Joseph Alexander, Fushimi Seiya, Tsubogo Tetsu, Kobayashi Shū
机构信息
Department of Chemistry, School of Science, The University of Tokyo.
Green & Sustainable Chemistry Cooperation Laboratory, Graduate School of Science, The University of Tokyo.
出版信息
Chem Pharm Bull (Tokyo). 2018;66(9):847-850. doi: 10.1248/cpb.c18-00485.
Asymmetric epoxidation reactions of chalcone derivatives catalyzed by chiral calcium complexes using hydrogen peroxide were developed. The epoxidation reactions proceeded smoothly to afford the desired products in good yields with good enantioselectivities. This is the first example of chiral calcium-catalyzed asymmetric epoxidation reactions using hydrogen peroxide as the terminal oxidant.
开发了使用过氧化氢在手性钙配合物催化下查尔酮衍生物的不对称环氧化反应。环氧化反应顺利进行，以良好的对映选择性和高收率得到所需产物。这是以过氧化氢作为终端氧化剂的手性钙催化不对称环氧化反应的首例。
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