Kawasaki Hiroshi
Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University.
Biol Pharm Bull. 2018;41(9):1324-1329. doi: 10.1248/bpb.b18-00142.
Folds of the cerebral cortex (gyri and sulci) are among the most important properties of the mammalian brain. Uncovering the physiological roles, developmental mechanisms and evolution of the cortical folds would greatly facilitate our understanding of the human brain and its diseases. Although the anatomical features of the cortical folds have been intensively investigated, our knowledge about their molecular bases is still limited. To overcome this limitation, we recently established rapid and efficient genetic manipulation techniques for the brain of gyrencephalic mammal ferrets (Mustela putorius furo). Using these techniques, we successfully uncovered the molecular mechanisms of cortical folding. In this article, I will summarize our recent research on the molecular mechanisms of development and diseases of cortical folding.
大脑皮层褶皱（脑回和脑沟）是哺乳动物大脑最重要的特征之一。揭示皮层褶皱的生理作用、发育机制和进化过程将极大地促进我们对人类大脑及其疾病的理解。尽管对皮层褶皱的解剖特征已进行了深入研究，但我们对其分子基础的了解仍然有限。为了克服这一局限,我们最近建立了针对脑回哺乳动物雪貂（白鼬）大脑的快速有效的基因操作技术。利用这些技术,我们成功揭示了皮层折叠的分子机制。在本文中,我将总结我们最近关于皮层折叠发育和疾病分子机制的研究。
