Castle Peak Hospital, Hong Kong, China.
Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
Early Interv Psychiatry. 2019 Oct;13(5):1099-1104. doi: 10.1111/eip.12733. Epub 2018 Sep 3.
The present study aimed to explore the two-year naturalistic trajectory of time- and event-based prospective memory (PM) in patients with first-episode schizophrenia.
We administered a computer-based dual-task PM paradigm to 57 individuals with first-episode schizophrenia at baseline and after 6 months, 12 months and 24 months. Forty-eight healthy controls were also recruited and completed all the measures at baseline. We compared the trajectories between time-based and event-based PM in first-episode schizophrenia patients using repeated measures ANOVAs, and examined the relationship between PM and clinical symptoms using Spearman's correlation.
PM impairments improved significantly after 24 months of follow-up. However, time-based and event-based PM appeared to run different trajectories. After 24 months, first-episode schizophrenia patient performed poorer than healthy controls in time-based but not event-based PM. PM did not appear to be correlated with clinical symptoms, both cross-sectionally and longitudinally.
This is one of the longest follow-up studies investigating PM in first-episode schizophrenia. Our results provide evidence to support that time-based PM is more temporally stable than event-based PM.
本研究旨在探索首发精神分裂症患者基于时间和基于事件的前瞻性记忆（PM）的两年自然轨迹。
我们在基线时以及 6 个月、12 个月和 24 个月后，使用基于计算机的双任务 PM 范式对 57 名首发精神分裂症患者进行了评估。还招募了 48 名健康对照者，并在基线时完成了所有测量。我们使用重复测量方差分析比较首发精神分裂症患者基于时间和基于事件的 PM 轨迹，并使用 Spearman 相关检验检查 PM 与临床症状之间的关系。
PM 损伤在 24 个月的随访后显著改善。然而，基于时间和基于事件的 PM 似乎呈现出不同的轨迹。在 24 个月时，首发精神分裂症患者在基于时间的 PM 上表现不如健康对照组，而在基于事件的 PM 上则没有差异。PM 与临床症状之间无论是在横断面还是在纵向均没有相关性。
这是最长的随访研究之一，旨在研究首发精神分裂症的 PM。我们的结果提供了证据支持基于时间的 PM 比基于事件的 PM 更具有时间稳定性。
