Goss-Varley Monika, Shoffstall Andrew J, Dona Keith R, McMahon Justin A, Lindner Sydney C, Ereifej Evon S, Capadona Jeffrey R
Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Department of Biomedical Engineering, Case Western Reserve University.
Advanced Platform Technology Center, Rehabilitation Research and Development, Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Department of Biomedical Engineering, Case Western Reserve University;
J Vis Exp. 2018 Aug 18(138):57829. doi: 10.3791/57829.
Medical devices implanted in the brain hold tremendous potential. As part of a Brain Machine Interface (BMI) system, intracortical microelectrodes demonstrate the ability to record action potentials from individual or small groups of neurons. Such recorded signals have successfully been used to allow patients to interface with or control computers, robotic limbs, and their own limbs. However, previous animal studies have shown that a microelectrode implantation in the brain not only damages the surrounding tissue but can also result in functional deficits. Here, we discuss a series of behavioral tests to quantify potential motor impairments following the implantation of intracortical microelectrodes into the motor cortex of a rat. The methods for open field grid, ladder crossing, and grip strength testing provide valuable information regarding the potential complications resulting from a microelectrode implantation. The results of the behavioral testing are correlated with endpoint histology, providing additional information on the pathological outcomes and impacts of this procedure on the adjacent tissue.
植入大脑的医疗设备具有巨大潜力。作为脑机接口（BMI）系统的一部分，皮层内微电极展示了记录单个或小群神经元动作电位的能力。此类记录信号已成功用于让患者与计算机、机器人肢体以及自身肢体进行交互或控制。然而，先前的动物研究表明，在大脑中植入微电极不仅会损伤周围组织，还可能导致功能缺陷。在此，我们讨论一系列行为测试，以量化将皮层内微电极植入大鼠运动皮层后潜在的运动损伤。旷场网格、爬梯和握力测试方法提供了有关微电极植入可能导致的并发症的有价值信息。行为测试结果与终点组织学相关，提供了有关该手术的病理结果及其对相邻组织影响的更多信息。
