Programa de Pós-graduação em Ciências Fisiológicas, Universidade Federal do Rio Grande-FURG, Rio Grande, Rio Grande do Sul, Brazil.
Instituto de Ciências Biológicas, Universidade Federal do Rio Grande (FURG), Rio Grande, Rio Grande do Sul, Brazil.
Bioessays. 2018 Nov;40(11):e800068. doi: 10.1002/bies.201800068. Epub 2018 Sep 3.
In recent years there has been a wealth of studies investigating how memories are allocated in the hippocampus. Some of those studies showed that it is possible to manipulate the identity of neurons recruited to represent a given memory without affecting the memory's behavioral expression. Those findings raised questions about how the hippocampus represents memories, with some researchers arguing that hippocampal neurons do not represent fixed stimuli. Herein, an alternative hypothesis is argued. Neurons in high-order brain regions can be tuned to multiple dimensions, forming complex, abstract representations. It is argued that such complex receptive fields allow those neurons to show some flexibility in their responses while still representing relatively fixed sets of stimuli. Moreover, it is pointed out that changes induced by artificial manipulation of cell assemblies are not completely redundant-the observed behavioral redundancy does not imply cognitive redundancy, as different, but similar, memories may induce the same behavior.
近年来，有大量研究调查了记忆是如何在海马体中分配的。其中一些研究表明，有可能在不影响记忆行为表达的情况下，操纵被招募来表示特定记忆的神经元的身份。这些发现引发了关于海马体如何表示记忆的问题，一些研究人员认为海马体神经元不代表固定的刺激。在此，提出了另一种假设。大脑高级区域的神经元可以被调谐到多个维度，形成复杂的、抽象的表示。有人认为，这种复杂的感受野允许这些神经元在反应中表现出一定的灵活性，同时仍然代表相对固定的刺激集。此外，还指出，通过人工操纵细胞集合诱导的变化并不是完全冗余的——观察到的行为冗余并不意味着认知冗余，因为不同但相似的记忆可能会引起相同的行为。
