普尼拉明诱导的青蛙骨骼肌挛缩。
Prenylamine-induced contracture of frog skeletal muscle.
作者信息
Kirsten E B, Lustig K C
出版信息
Br J Pharmacol. 1977 May;60(1):97-105. doi: 10.1111/j.1476-5381.1977.tb16753.x.
Abstract
- Experiments were performed to determine the influence of prenylamine on excitation-contraction coupling in frog sartorius muscle. 2. Prenylamine (0.2-1.0 mM) produced a biphasic contracture in skeletal muscle characterized by an initial phasic and subsequent tonic contracture. 3. Neither dantrolene nor procaine blocked the prenylamine-induced contracture. Pretreatment with 100 mM K+ blocked the phasic but not the tonic component of the prenylamine contracture. 4. Prenylamine produced a sustained increase in 45Ca efflux at all concentrations that produce contracture. These concentrations of prenylamine also depressed the action potential, muscle twitch and resting potential. 5. Low concentrations of prenylamine (0.05 mM) which produced neither contracture, 45Ca efflux nor 45Ca influx, depressed the action potential, muscle twitch and K+ contracture. 6. The results suggest that prenylamine not only alters calcium mobility but also membrane permeability to other ions.
摘要
- 进行实验以确定普尼拉明对青蛙缝匠肌兴奋 - 收缩偶联的影响。2. 普尼拉明（0.2 - 1.0 mM）在骨骼肌中产生双相挛缩，其特征为初始的相性挛缩和随后的强直性挛缩。3. 丹曲林和普鲁卡因均不能阻断普尼拉明诱导的挛缩。用100 mM K⁺预处理可阻断普尼拉明挛缩的相性成分，但不能阻断强直性成分。4. 在所有产生挛缩的浓度下，普尼拉明都会使⁴⁵Ca外流持续增加。这些浓度的普尼拉明还会降低动作电位、肌肉抽搐和静息电位。5. 低浓度的普尼拉明（0.05 mM）既不产生挛缩、⁴⁵Ca外流也不产生⁴⁵Ca内流，但会降低动作电位、肌肉抽搐和K⁺挛缩。6. 结果表明，普尼拉明不仅改变钙的移动性，还改变膜对其他离子的通透性。
相似文献
1
Prenylamine-induced contracture of frog skeletal muscle.普尼拉明诱导的青蛙骨骼肌挛缩。
Br J Pharmacol. 1977 May;60(1):97-105. doi: 10.1111/j.1476-5381.1977.tb16753.x.
2
Effects of verapamil on excitation-contraction coupling in frog sartorius muscle.维拉帕米对蛙缝匠肌兴奋-收缩偶联的影响。
J Pharmacol Exp Ther. 1978 Apr;205(1):49-57.
3
Effects of 4-aminopyridine on the excitation-contraction coupling in frog and rat skeletal muscle.4-氨基吡啶对青蛙和大鼠骨骼肌兴奋-收缩偶联的影响。
Acta Physiol Scand. 1979 Apr;105(4):443-52. doi: 10.1111/j.1748-1716.1979.tb00109.x.
4
Excitation, contraction, and excitation-contraction coupling of frog muscles in hypotonic solutions.低渗溶液中青蛙肌肉的兴奋、收缩及兴奋-收缩偶联
Life Sci I. 1972 May 1;11(9):449-60. doi: 10.1016/0024-3205(72)90117-8.
5
The effect of lanthanum on excitation-contraction coupling in frog skeletal muscle.镧对青蛙骨骼肌兴奋-收缩偶联的影响。
Can J Physiol Pharmacol. 1974 Dec;52(6):1126-35. doi: 10.1139/y74-148.
6
Effect of ruthenium red on excitation-contraction coupling in frog skeletal muscle.钌红对青蛙骨骼肌兴奋-收缩偶联的影响。
Jpn J Physiol. 1980;30(1):49-59. doi: 10.2170/jjphysiol.30.49.
7
The site of action of AHR-2666 in frog sartorius muscle.AHR - 2666在青蛙缝匠肌中的作用部位。
J Pharmacol Exp Ther. 1974 Oct;191(1):156-63.
8
Quinine and caffeine effects on 45Ca movements in frog sartorius muscle.奎宁和咖啡因对青蛙缝匠肌中45钙运动的影响。
J Gen Physiol. 1967 Sep;50(8):2109-28. doi: 10.1085/jgp.50.8.2109.
9
[Influence of chlorpromazine, prenylamine, imipramine and reserpine on calcium exchange and muscle function (m. rectus and sartorius of frog)].[氯丙嗪、普尼拉明、丙咪嗪和利血平对钙交换及肌肉功能（青蛙的直肌和缝匠肌）的影响]
Naunyn Schmiedebergs Arch Pharmakol. 1969;264(2):129-46.
10
Calcium influx in contracting and paralyzed frog twitch muscle fibers.收缩和麻痹的青蛙抽动肌纤维中的钙内流。
J Gen Physiol. 1985 Mar;85(3):383-408. doi: 10.1085/jgp.85.3.383.
引用本文的文献
1
Pharmacology of calcium release from sarcoplasmic reticulum.肌浆网钙释放的药理学
J Bioenerg Biomembr. 1989 Apr;21(2):295-320. doi: 10.1007/BF00812074.
本文引用的文献
1
The Effect of Caffeine on Radiocalcium Movement in Frog Sartorius.咖啡因对蛙直肌中放射性钙运动的影响。
J Gen Physiol. 1961 May 1;44(5):845-58. doi: 10.1085/jgp.44.5.845.
2
Striated muscle.横纹肌
Annu Rev Physiol. 1974;36:461-502. doi: 10.1146/annurev.ph.36.030174.002333.
3
4
INHIBITION OF CAFFEINE RIGOR AND RADIOCALCIUM MOVEMENTS BY LOCAL ANESTHETICS IN FROG SARTORIUS MUSCLE.局部麻醉药对蛙缝匠肌中咖啡因强直和放射性钙运动的抑制作用
J Gen Physiol. 1963 Sep;47(1):151-72. doi: 10.1085/jgp.47.1.151.
5
6
The distribution and kinetics of release of radiocalcium in tendon and skeletal muscle.放射性钙在肌腱和骨骼肌中的分布及释放动力学。
J Gen Physiol. 1959 May 20;42(5):1123-37. doi: 10.1085/jgp.42.5.1123.
7
Calcium influx in skeletal muscle at rest, during activity, and during potassium contracture.静息、活动及钾离子挛缩期间骨骼肌中的钙内流。
J Gen Physiol. 1959 Mar 20;42(4):803-15. doi: 10.1085/jgp.42.4.803.
8
Quinine and caffeine effects on 45Ca movements in frog sartorius muscle.奎宁和咖啡因对青蛙缝匠肌中45钙运动的影响。
J Gen Physiol. 1967 Sep;50(8):2109-28. doi: 10.1085/jgp.50.8.2109.
9
1-[(5-arylfurfurylidene)amino]hydantoins. A new class of muscle relaxants.1-[(5-芳基糠叉基)氨基]乙内酰脲。一类新型肌肉松弛剂。
J Med Chem. 1967 Sep;10(5):807-10. doi: 10.1021/jm00317a011.
10
Action of local anesthetics on coupling systems in muscle.局部麻醉药对肌肉中偶联系统的作用。
J Pharmacol Exp Ther. 1967 Aug;157(2):388-405.
Zotero 插件