School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China; China National Environmental Monitoring Center, Beijing 100012, China.
School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Sci Total Environ. 2019 Feb 1;649:731-738. doi: 10.1016/j.scitotenv.2018.08.157. Epub 2018 Aug 13.
This study was designed to test whether the dietary intake of polycyclic aromatic hydrocarbons (PAHs) is a potential exposure source relating to the high cancer incidence area in southwest China. Duplicate plate method was used to collect food samples in rural and urban sites in the region. Questionnaire surveys were conducted among 300 local residents to obtain their dietary habits and 50 subjects were chosen to collect the samples. The 16 priority PAHs (PAH) in composite food samples for each individual subject were measured, and non-carcinogenic and carcinogenic risks were analyzed based on the results of Monte Carlo method. The average concentration of the PAH in food samples was 12.04 ± 8.52 ng g. The life time average daily benzo(a)pyrene equivalent (BaP) exposure dose was 6.07 × 10 mg kg day. Although non-carcinogenic risk was found to be within a controllable range, the average incremental lifetime cancer risk (ILCR) was 3.7 × 10 for rural subjects and 6.1 × 10 for urban subjects, which is comparable with other regions in China. The serious risk level of 10 was exceeded by 10.7% of urban residents and 2.1% of rural residents. This study implies that dietary exposure to PAHs is a potential exposure source to the high cancer in the region, and further cancer risk control strategies need to be formulated.
本研究旨在测试多环芳烃（PAHs）的饮食摄入是否是与中国西南地区高发癌症地区相关的潜在暴露源。采用双平板法在该地区的农村和城市地点收集食物样本。对 300 名当地居民进行问卷调查，以了解他们的饮食习惯，并选择 50 名受试者收集样本。对每位个体受试者的复合食物样本中的 16 种优先 PAHs（PAH）进行了测量，并基于蒙特卡罗方法的结果分析了非致癌和致癌风险。食物样本中 PAH 的平均浓度为 12.04 ± 8.52 ng g。终生平均每日苯并（a）芘等效剂量（BaP）暴露剂量为 6.07 × 10 mg kg day。虽然发现非致癌风险处于可控范围内，但农村受试者的平均增量终生癌症风险（ILCR）为 3.7 × 10，城市受试者为 6.1 × 10，与中国其他地区相当。10%的城市居民和 2.1%的农村居民超过了严重风险水平 10。本研究表明，饮食摄入 PAHs 是该地区癌症高发的潜在暴露源，需要制定进一步的癌症风险控制策略。
