La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, San Diego, CA, 92037, USA.
Mol Immunol. 2018 Sep;101:564-573. doi: 10.1016/j.molimm.2018.08.020. Epub 2018 Aug 31.
During the last years, intensive research has shed light in the transcriptional networks that shape the invariant NKT (iNKT) cell lineage and guide the choices towards functionally distinct iNKT cell subsets (Constantinides and Bendelac, 2013; Engel and Kronenberg, 2014; Gapin, 2016; Kim et al., 2015). However, the epigenetic players that regulate gene expression and orchestrate the iNKT cell lineage choices remain poorly understood. Here, we summarize recent advances in our understanding of epigenetic regulation of iNKT cell development and lineage choice. Particular emphasis is placed on DNA modifications and the Ten Eleven Translocation (TET) family of DNA demethylases.
在过去的几年中，密集的研究揭示了调节不变自然杀伤 T（iNKT）细胞谱系形成并指导其向功能不同的 iNKT 细胞亚群分化的转录网络（Constantinides 和 Bendelac，2013；Engel 和 Kronenberg，2014；Gapin，2016；Kim 等人，2015）。然而，调控基因表达并协调 iNKT 细胞谱系选择的表观遗传调控因子仍知之甚少。在这里，我们总结了我们对 iNKT 细胞发育和谱系选择的表观遗传调控的理解的最新进展。特别强调了 DNA 修饰和 Ten Eleven Translocation（TET）家族的 DNA 去甲基化酶。
