TET 蛋白成为焦点：T 细胞生物学中表观遗传调控的新观点。
TET Proteins in the Spotlight: Emerging Concepts of Epigenetic Regulation in T Cell Biology.
机构信息
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC; and Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC.
出版信息
Immunohorizons. 2023 Jan 1;7(1):106-115. doi: 10.4049/immunohorizons.2200067.
Ten-eleven translocation (TET) proteins are dioxygenases that oxidize 5-methylcytosine to form 5-hydroxymethylcytosine and downstream oxidized modified cytosines. In the past decade, intensive research established that TET-mediated DNA demethylation is critical for immune cell development and function. In this study, we discuss major advances regarding the role of TET proteins in regulating gene expression in the context of T cell lineage specification, function, and proliferation. Then, we focus on open questions in the field. We discuss recent findings regarding the diverse roles of TET proteins in other systems, and we ask how these findings might relate to T cell biology. Finally, we ask how this tremendous progress on understanding the multifaceted roles of TET proteins in shaping T cell identity and function can be translated to improve outcomes of human disease, such as hematological malignancies and immune response to cancer.
十十一转位（TET）蛋白是双加氧酶，可将 5-甲基胞嘧啶氧化为 5-羟甲基胞嘧啶，并进一步氧化修饰下游的胞嘧啶。在过去的十年中，大量研究证实 TET 介导的 DNA 去甲基化对于免疫细胞的发育和功能至关重要。在本研究中，我们讨论了 TET 蛋白在调节 T 细胞谱系特化、功能和增殖过程中基因表达的主要进展。然后，我们关注该领域的开放性问题。我们讨论了关于 TET 蛋白在其他系统中发挥多种作用的最新发现，并探讨了这些发现与 T 细胞生物学的关系。最后，我们探讨了在理解 TET 蛋白在塑造 T 细胞特性和功能方面的多方面作用方面取得的巨大进展，如何能够转化为改善人类疾病的结果，例如血液恶性肿瘤和对癌症的免疫反应。
Zotero 插件