Romano E Silva Ana Catarina, Dias Glauber Monteiro, de Carvalho Jorge José, De Lorenzo Andrea, Kasal Daniel Arthur Barata
National Institute of Cardiology, Ministry of Health, Rua das Laranjeiras No. 374, Rio de Janeiro, RJ, 22240-006, Brazil.
Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
BMC Res Notes. 2018 Sep 3;11(1):635. doi: 10.1186/s13104-018-3743-5.
Diabetes mellitus patients (DM) have more severe progression of atherosclerotic disease than non-diabetic (NDM) individuals. In situ inflammation and oxidative stress are key points in the pathophysiology of atherosclerosis, a concept largely based on animal model research. There are few studies comparing inflammation and oxidative stress parameters in medium-sized arteries between DM and NDM patients. A fragment of the internal mammary artery used in coronary artery bypass grafting (CABG) will be employed for this purpose OBJECTIVE: To assess the expression of inflammatory markers tumor necrosis factor-α, transforming growth factor-β1, nuclear factor kappa B, the enzymes superoxide dismutase, and catalase in the vascular wall of the arterial graft used in CABG, comparing DM and NDM patients RESULTS: The present study will add information to the vascular degenerative processes occurring in diabetic patients.
糖尿病患者（DM）比非糖尿病患者（NDM）的动脉粥样硬化疾病进展更为严重。原位炎症和氧化应激是动脉粥样硬化病理生理学的关键点，这一概念很大程度上基于动物模型研究。比较DM和NDM患者中、小动脉炎症和氧化应激参数的研究较少。为此，将采用冠状动脉旁路移植术（CABG）中使用的一段乳内动脉。目的：评估CABG中使用的动脉移植物血管壁中炎症标志物肿瘤坏死因子-α、转化生长因子-β1、核因子κB、超氧化物歧化酶和过氧化氢酶的表达，比较DM和NDM患者。结果：本研究将为糖尿病患者发生的血管退行性过程增添信息。
