Sleep and Heart Laboratory, Pronto Socorro Cardiológico de Pernambuco (PROCAPE) da Universidade de Pernambuco, Brasil.
Pronto Socorro Cardiológico de Pernambuco (PROCAPE) da Universidade de Pernambuco, Recife, Brasil.
J Clin Sleep Med. 2018 Sep 15;14(9):1471-1475. doi: 10.5664/jcsm.7316.
The aim of the current study was to evaluate the association between obstructive sleep apnea (OSA) and exercise capacity in middle-aged women.
Consecutive middle-aged female subjects without cardiovascular disease, aged 45 to 65 years, from two gynecological clinics underwent detailed clinical evaluation, portable sleep study, and treadmill exercise test.
We studied 232 women (age: 55.6 ± 5.2 years; body mass index [BMI]: 28.0 ± 4.8 kg/m). OSA (apnea-hypopnea index ≥ 5 events/h) was diagnosed in 90 (39%) and obesity (BMI > 30 kg/m) in 76 (33%) women, respectively. Participants with OSA were older, had a higher BMI, and an increased frequency of arterial hypertension compared to women without OSA. Multiple logistic regression models were used to evaluate the association between OSA and exercise capacity, controlling for traditional risk factors including BMI, age, hypertension, diabetes, and sedentary lifestyle. In multivariate analysis, the presence of obesity without OSA was associated with low exercise capacity (odds ratio [OR] 2.88, 95% confidence interval [CI] 1.02-8.11, = .045), whereas the presence of OSA without obesity was not (OR 1.07, 95% CI 0.31-3.69, = .912). However, the coexistence of obesity and OSA increased markedly the odds of reduction in exercise capacity (OR 9.40, CI 3.79-23.3, < .001).
Obesity and OSA are common conditions in middle-aged women and may interact to reduce exercise capacity. These results highlight the importance of obesity control programs among women, as well as the diagnosis of comorbid OSA in older women.
本研究旨在评估中年女性阻塞性睡眠呼吸暂停（OSA）与运动能力之间的关系。
从两家妇科诊所连续纳入无心血管疾病、年龄在 45 至 65 岁之间的中年女性患者，进行详细的临床评估、便携式睡眠研究和跑步机运动测试。
共纳入 232 名女性（年龄：55.6 ± 5.2 岁；体重指数 [BMI]：28.0 ± 4.8 kg/m²）。分别诊断 90 名（39%）和 76 名（33%）女性患有 OSA（呼吸暂停低通气指数 [AHI]≥5 次/小时）和肥胖症（BMI＞30 kg/m²）。与无 OSA 的女性相比，患有 OSA 的女性年龄较大、BMI 较高且动脉高血压的发生频率更高。采用多变量逻辑回归模型，在校正 BMI、年龄、高血压、糖尿病和久坐不动的生活方式等传统危险因素后，评估 OSA 与运动能力之间的关系。在多变量分析中，无 OSA 的肥胖症与运动能力降低相关（比值比 [OR] 2.88，95%置信区间 [CI] 1.02-8.11，.045），而无肥胖症的 OSA 则不相关（OR 1.07，95% CI 0.31-3.69，.912）。然而，肥胖症和 OSA 的共存显著增加了运动能力下降的几率（OR 9.40，CI 3.79-23.3，.001）。
肥胖症和 OSA 是中年女性常见的病症，可能相互作用，降低运动能力。这些结果强调了在女性中实施肥胖症控制计划的重要性，以及对老年女性合并 OSA 的诊断。
