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肥胖对患有阻塞性睡眠呼吸暂停的肥胖女性肺功能和运动耐力的影响。

Influence of obesity in pulmonary function and exercise tolerance in obese women with obstructive sleep apnea.

作者信息

Passos Vivian Maria Moraes, Lima Anna Myrna Jaguaribe de, Leite Bárbara Renatha Afonso Ferreira de Barros, Pedrosa Rodrigo Pinto, Barros Isly Maria Lucena de, Costa Laura Olinda Bregieiro Fernandes, Santos Amilton da Cruz, Brasileiro-Santos Maria do Socorro

机构信息

Centro Integrado de Saúde Amaury de Medeiros, Universidade de Pernambuco (UPE), Recife, PE, Brasil.

Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco (UFRPE), Recife, PE, Brasil.

出版信息

Arch Endocrinol Metab. 2019 Feb;63(1):40-46. doi: 10.20945/2359-3997000000101.

Abstract

OBJECTIVE

To evaluate the influence of obesity on pulmonary function and exercise tolerance in women with obstructive sleep apnea (OSA).

SUBJECTS AND METHODS

A descriptive analytic cross- sectional study was carried out. Thirty-nine (39) sedentary climacteric women, aged 45 to 60 years, were evaluated and submitted to polysomnography. The participants were divided into 4 groups: a) 'eutrophic non-OSA' (n = 13); b) 'eutrophic OSA' (n = 5); c) 'obese non-OSA' (n = 6); d) 'obese OSA' (n = 15). All subjects underwent clinical and anthropometric evaluation, followed by pulmonary function tests and 6-minute walk test (6MWT).

RESULTS

There was a significant difference in the predicted percentage values of FEV1/FVC when comparing 'eutrophic OSA' and 'obese OSA' (97.6% ± 6.1% vs. 105.7% ± 5.7%, respectively; p = 0.025). The other spirometric variables did not show any differences between the studied groups. There was no significant difference in the maximum distance walked when the 'eutrophic non-OSA', 'eutrophic OSA', 'obese non-OSA' and 'obese OSA' groups were compared.

CONCLUSION

Considering the results of this study, OSA itself did not influence pulmonary function or functional capacity parameters compared to eutrophic women. However, not only isolated obesity but also obesity associated with OSA can negatively impact sleep quality and lung function.

摘要

目的

评估肥胖对阻塞性睡眠呼吸暂停(OSA)女性肺功能和运动耐力的影响。

对象与方法

开展一项描述性分析横断面研究。对39名年龄在45至60岁的久坐更年期女性进行评估并进行多导睡眠图检查。参与者被分为4组:a)“营养正常非OSA组”(n = 13);b)“营养正常OSA组”(n = 5);c)“肥胖非OSA组”(n = 6);d)“肥胖OSA组”(n = 15)。所有受试者均接受临床和人体测量学评估,随后进行肺功能测试和6分钟步行试验(6MWT)。

结果

比较“营养正常OSA组”和“肥胖OSA组”时,FEV1/FVC的预测百分比值存在显著差异(分别为97.6%±6.1%和105.7%±5.7%;p = 0.025)。其他肺量计变量在各研究组之间未显示出任何差异。比较“营养正常非OSA组”、“营养正常OSA组”、“肥胖非OSA组”和“肥胖OSA组”时,最大步行距离没有显著差异。

结论

考虑到本研究的结果,与营养正常的女性相比,OSA本身并未影响肺功能或功能能力参数。然而,不仅单纯肥胖,而且与OSA相关的肥胖都会对睡眠质量和肺功能产生负面影响。

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Physiology of obesity and effects on lung function.肥胖的生理学和对肺功能的影响。
J Appl Physiol (1985). 2010 Jan;108(1):206-11. doi: 10.1152/japplphysiol.00694.2009. Epub 2009 Oct 29.

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