Tay J, Costanzi A, Basello K, Piuri G, Ferrazzi E, Speciani A F, Lees C C
Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
Cryolab University of Rome Tor Vergata, Via Montpellier, 1 - 00133 Rome, Italy.
Pregnancy Hypertens. 2018 Jul;13:58-61. doi: 10.1016/j.preghy.2018.05.001. Epub 2018 May 3.
The objective of this study was the analysis of B-Cell Activating Factor (BAFF) levels in pregnancies affected by PE, and in pregnancies affected by fetal growth restriction without Hypertensive disorders and its possible correlation with pulse wave velocity and cardiac output.
Prospective study of 69 women at 24-40 weeks gestation. Haemodynamic function was assessed in those with Pre-eclampsia (PE, n = 19), fetal growth restriction (FGR, n = 10) and healthy pregnancies (n = 40). Maternal venous BAFF levels at recruitment were measured using ELISA. We analysed the relationship between BAFF and cardiac output (CO), and BAFF and PWV (pulse wave velocity); the gold standard for assessing arterial stiffness. PWV was measured with an oscillometric device and CO using inert gas rebreathing technique. PWV and CO were converted to gestation adjusted indices (z scores).
The association between BAFF levels in PE and FGR, and the relationship of BAFF with PWV and CO.
BAFF was higher in PE (p = 0.03) but not in FGR (p = 0.83) when compared to healthy pregnancies. There was a positive correlation between BAFF levels and z score PWV (r = 0.25, p = 0.04), but not CO (r = -0.01, p = 0.91). BAFF levels did not change with gestational age. (r = 0.012, p = 0.925).
These findings provide evidence of a possible contribution of BAFF to both maternal inflammation and arterial dysfunction associated with PE. Though no relationship was found with another disorder of placentation: normotensive FGR, this condition is not thought to be associated with maternal inflammation.
本研究的目的是分析子痫前期（PE）孕妇、无高血压疾病的胎儿生长受限（FGR）孕妇体内B细胞活化因子（BAFF）水平，及其与脉搏波速度和心输出量的可能相关性。
对69例妊娠24 - 40周的女性进行前瞻性研究。对患有子痫前期（PE，n = 19）、胎儿生长受限（FGR，n = 10）和正常妊娠（n = 40）的孕妇进行血流动力学功能评估。招募时使用酶联免疫吸附测定法（ELISA）测量孕妇静脉血中BAFF水平。我们分析了BAFF与心输出量（CO）以及BAFF与脉搏波速度（PWV，评估动脉僵硬度的金标准）之间的关系。使用示波装置测量PWV，采用惰性气体再呼吸技术测量CO。将PWV和CO转换为孕周校正指数（z评分）。
PE和FGR中BAFF水平的关联，以及BAFF与PWV和CO的关系。
与正常妊娠相比，PE患者的BAFF水平较高（p = 0.03），而FGR患者的BAFF水平无差异（p = 0.83）。BAFF水平与z评分PWV呈正相关（r = 0.25，p = 0.04），但与CO无相关性（r = -0.01，p = 0.91）。BAFF水平不随孕周变化（r = 0.012，p = 0.925）。
这些发现提供了证据，表明BAFF可能与PE相关的母体炎症和动脉功能障碍有关。虽然未发现与另一种胎盘形成障碍——血压正常的FGR存在关联，但这种情况被认为与母体炎症无关。
