Inflammation Society, 18 Woodlands Park, Bexley DA52EL, UK.
GEK lab-Cryolab, University of Rome Tor Vergata, Via Montpellier, 1-00133 Rome, Italy.
Nutrients. 2020 Feb 14;12(2):479. doi: 10.3390/nu12020479.
In gestational diabetes mellitus (GDM), pancreatic β-cell breakdown can result from a proinflammatory imbalance created by a sustained level of cytokines. In this study, we investigated the role of specific cytokines, such as B-cell activating factor (BAFF), tumor necrosis factor α (TNF-α), and platelet-activating factor (PAF), together with methylglyoxal (MGO) and glycated albumin (GA) in pregnant women affected by GDM.
We enrolled 30 women whose inflammation and metabolic markers were measured at recruitment and after 12 weeks of strict dietetic therapy. We compared these data to the data obtained from 53 randomly selected healthy nonpregnant subjects without diabetes, hyperglycemia, or any condition that can affect glycemic metabolism.
In pregnant women affected by GDM, PAF levels increased from 26.3 (17.4-47.5) ng/mL to 40.1 (30.5-80.5) ng/mL ( < 0.001). Their TNF-α levels increased from 3.0 (2.8-3.5) pg/mL to 3.4 (3.1-5.8) pg/mL ( < 0.001). The levels of methylglyoxal were significantly higher in the women with GDM ( < 0.001), both at diagnosis and after 12 weeks (0.64 (0.46-0.90) μg/mL; 0.71 (0.47-0.93) μg/mL, respectively) compared to general population (0.25 (0.19-0.28) μg/mL). Levels of glycated albumin were significantly higher in women with GDM ( < 0.001) only after 12 weeks from diagnosis (1.51 (0.88-2.03) nmol/mL) compared to general population (0.95 (0.63-1.4) nmol/mL).
These findings support the involvement of new inflammatory and metabolic biomarkers in the mechanisms related to GDM complications and prompt deeper exploration into the vicious cycle connecting inflammation, oxidative stress, and metabolic results.
在妊娠糖尿病（GDM）中，胰岛β细胞的衰竭可能是由细胞因子持续水平引起的促炎失衡所致。在这项研究中，我们研究了特定细胞因子（如 B 细胞激活因子（BAFF）、肿瘤坏死因子α（TNF-α）和血小板激活因子（PAF））以及甲基乙二醛（MGO）和糖化白蛋白（GA）在患有 GDM 的孕妇中的作用。
我们招募了 30 名女性，在招募时和严格饮食治疗 12 周后测量了她们的炎症和代谢标志物。我们将这些数据与 53 名随机选择的健康非妊娠、无糖尿病、高血糖或任何影响血糖代谢的疾病的非妊娠受试者的数据进行了比较。
患有 GDM 的孕妇的 PAF 水平从 26.3（17.4-47.5）ng/mL 增加到 40.1（30.5-80.5）ng/mL（<0.001）。她们的 TNF-α水平从 3.0（2.8-3.5）pg/mL 增加到 3.4（3.1-5.8）pg/mL（<0.001）。患有 GDM 的女性的甲基乙二醛水平明显更高（<0.001），无论是在诊断时还是在 12 周后（0.64（0.46-0.90）μg/mL；0.71（0.47-0.93）μg/mL，分别）与一般人群（0.25（0.19-0.28）μg/mL）相比。仅在诊断后 12 周，患有 GDM 的女性的糖化白蛋白水平明显更高（<0.001）（1.51（0.88-2.03）nmol/mL）与一般人群（0.95（0.63-1.4）nmol/mL）相比。
这些发现支持新的炎症和代谢生物标志物参与与 GDM 并发症相关的机制，并促使更深入地探索炎症、氧化应激和代谢结果之间的恶性循环。
